Vachhani Arpit Vallabhbhai, Barvaliya Manish, Naik Viren, Jha Pramod, Tripathi Chandrabhanu
Department of Pharmacology; Department of Medicine, Government Medical College, Gujarat, India.
Infez Med. 2015 Jun;23(2):155-60.
To compare the bacteriological cure rate of short-course (3-day) treatment of uncomplicated urinary tract infection (UTI) using co-trimoxazole, norfloxacin and levofloxacin, patients with uncomplicated UTI were randomized to receive either co-trimoxazole (960 mg) twice a day or norfloxacin (400 mg) twice a day or levofloxacin (250 mg) once a day for three days. Urine culture was done at the end of treatment and evaluated for bacteriological cure rate in each group. Among a total of 175 patients, Escherichia coli (74.29%) was the most common organism isolated followed by Klebsiella (11.43%), Streptococcus (6.29%), Staphylococcus saphrophyticus (5.14%), and Pseudomonas (2.86%). At the end of three days' treatment, bacteriological cure rates were 86.2%, 87.7% and 83.3% for co-trimoxazole, norfloxacin and levofloxacin, respectively (p>0.05). Therefore short-course treatment with co-trimoxazole 960 mg twice a day, norfloxacin 400 mg twice a day and levofloxacin 250 mg once a day are almost equally effective for treatment of uncomplicated UTI.
为比较使用复方新诺明、诺氟沙星和左氧氟沙星短程（3天）治疗单纯性尿路感染（UTI）的细菌学治愈率，将单纯性UTI患者随机分组，分别接受复方新诺明（960毫克）每日2次、诺氟沙星（400毫克）每日2次或左氧氟沙星（250毫克）每日1次，疗程均为3天。治疗结束时进行尿培养，并评估每组的细菌学治愈率。在总共175例患者中，分离出的最常见病原体为大肠杆菌（74.29%），其次为克雷伯菌（11.43%）、链球菌（6.29%）、腐生葡萄球菌（5.14%）和假单胞菌（2.86%）。治疗3天后，复方新诺明、诺氟沙星和左氧氟沙星的细菌学治愈率分别为86.2%、87.7%和83.3%（p>0.05）。因此，每日2次服用960毫克复方新诺明、每日2次服用400毫克诺氟沙星以及每日1次服用250毫克左氧氟沙星的短程治疗对单纯性UTI的治疗效果几乎相同。
