Pereira S A R, Florêncio C M G D, Marinheiro J C, Hársi C M, Moura F E A
Departmento de Patologia e Medicina Legal,Universidade Federal do Ceará (UFC),Brazil.
Instituto de Ciências Biomédicas,Universidade de São Paulo (USP),Brazil.
Epidemiol Infect. 2016 Jan;144(2):355-62. doi: 10.1017/S0950268815000916. Epub 2015 Jun 26.
Human adenoviruses (HAdVs) are important respiratory pathogens, found in 2-27% of acute respiratory infection (ARI) cases. Few studies have analysed the diversity of species and types of HAdVs associated with ARI in Brazil. The purpose of this study was to determine the circulation patterns of the different HAdV species and respective types associated with ARI in children in the city of Fortaleza, northeastern Brazil. HAdVs were screened by an indirect immunofluorescence assay, and subsequently identified as species and types by PCR and sequencing of the hexon gene (HVR1-HVR6). Between 2001 and 2013, a total of 290 HAdV strains were detected, 190 of which were identified as belonging to the HAdV-B, -C and -E species. Seven types of HAdVs circulated in the studied population during the analysed period, with HAdV-3 being predominant.
人腺病毒（HAdVs）是重要的呼吸道病原体，在2%至27%的急性呼吸道感染（ARI）病例中被发现。很少有研究分析巴西与ARI相关的HAdV物种和类型的多样性。本研究的目的是确定巴西东北部福塔莱萨市儿童中与ARI相关的不同HAdV物种及其各自类型的流行模式。通过间接免疫荧光试验对HAdVs进行筛查，随后通过PCR和六邻体基因（HVR1-HVR6）测序确定其物种和类型。2001年至2013年期间，共检测到290株HAdV菌株，其中190株被鉴定为属于HAdV-B、-C和-E物种。在分析期间，七种类型的HAdVs在研究人群中流行，其中HAdV-3占主导地位。
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