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用已证实的心血管疾病预防方法预防侵袭性前列腺癌。

Preventing aggressive prostate cancer with proven cardiovascular disease preventive methods.

作者信息

Moyad Mark A

机构信息

Department of Urology, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA.

出版信息

Asian J Androl. 2015 Nov-Dec;17(6):874-7; discussion 876. doi: 10.4103/1008-682X.156854.

Abstract

Cardiovascular disease (CVD) has been the number one cause of death in the U.S. for 114 of the last 115 years. Risk factors for prostate cancer have primarily mirrored risk proven risk factors for CVD, especially aggressive disease. Obesity, dyslipidemia, glucose intolerance, metabolic syndrome, unhealthy dietary habits or caloric excess, lack of physical activity, and inflammation are just some of these shared risk factors. The evidence also suggests proven CVD preventive measures are identical to prostate cancer preventive measures, especially in regard to aggressive disease. Thus, apart from lifestyle measures that can encourage optimal heart and prostate health there are potentially several dietary supplements that need to be avoided in healthy men because they may also increase the risk of prostate cancer. However, there are also several low-cost, generic, safe in the appropriate individuals, and naturally derived agents that could reduce prostate cancer risk, and these can be discussed and remembered utilizing the acronym S.A.M. (statins, aspirin, and/or metformin).

摘要

在过去115年中的114年里,心血管疾病(CVD)一直是美国的头号死因。前列腺癌的危险因素主要反映了已证实的心血管疾病危险因素,尤其是侵袭性疾病的危险因素。肥胖、血脂异常、葡萄糖不耐受、代谢综合征、不健康的饮食习惯或热量过剩、缺乏体育活动以及炎症只是其中一些共同的危险因素。证据还表明,已证实的心血管疾病预防措施与前列腺癌预防措施相同,尤其是对于侵袭性疾病。因此,除了有助于促进心脏和前列腺健康的生活方式措施外,健康男性可能还需要避免几种膳食补充剂,因为它们也可能增加前列腺癌的风险。然而,也有几种低成本、普通、对适当个体安全且天然衍生的药物可以降低前列腺癌风险,这些可以用首字母缩写词S.A.M.(他汀类药物、阿司匹林和/或二甲双胍)来讨论和记忆。

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