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Asian J Androl. 2015 Nov-Dec;17(6):874-7; discussion 876. doi: 10.4103/1008-682X.156854.
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Aspirin, NSAIDs, and risk of prostate cancer: results from the REDUCE study.阿司匹林、非甾体抗炎药与前列腺癌风险:REDUCE研究结果
Clin Cancer Res. 2015 Feb 15;21(4):756-62. doi: 10.1158/1078-0432.CCR-14-2235. Epub 2014 Dec 17.
2
Effects of the Dietary Approach to Stop Hypertension (DASH) diet on cardiovascular risk factors: a systematic review and meta-analysis.终止高血压膳食疗法(DASH)饮食对心血管危险因素的影响:一项系统评价和荟萃分析。
Br J Nutr. 2015 Jan 14;113(1):1-15. doi: 10.1017/S0007114514003341. Epub 2014 Nov 28.
3
Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1- and Ripk3-dependent necrosis in C4-2B osseous metastatic castration-resistant prostate cancer cells.辛伐他汀与二甲双胍联合使用可诱导C4-2B骨转移性去势抵抗性前列腺癌细胞发生G1期细胞周期阻滞以及Ripk1和Ripk3依赖性坏死。
Cell Death Dis. 2014 Nov 20;5(11):e1536. doi: 10.1038/cddis.2014.500.
4
Primary prevention of colorectal cancer: myth or reality?结直肠癌的一级预防:神话还是现实?
World J Gastroenterol. 2014 Nov 7;20(41):15060-9. doi: 10.3748/wjg.v20.i41.15060.
5
Health policy: Male health--a recent paradigm.卫生政策:男性健康——一种新范式。
Nat Rev Urol. 2015 Jan;12(1):15-6. doi: 10.1038/nrurol.2014.306. Epub 2014 Nov 11.
6
Daily aspirin use and prostate cancer-specific mortality in a large cohort of men with nonmetastatic prostate cancer.每日使用阿司匹林与非转移性前列腺癌患者前列腺癌特异性死亡率的相关性:一项大型队列研究。
J Clin Oncol. 2014 Nov 20;32(33):3716-22. doi: 10.1200/JCO.2013.54.8875. Epub 2014 Oct 20.
7
Influence of Dietary Approaches to Stop Hypertension (DASH) diet on blood pressure: a systematic review and meta-analysis on randomized controlled trials.饮食预防高血压(DASH)饮食对血压的影响:一项关于随机对照试验的系统评价和荟萃分析
Nutr Metab Cardiovasc Dis. 2014 Dec;24(12):1253-61. doi: 10.1016/j.numecd.2014.06.008. Epub 2014 Jun 27.
8
Aspirin, cyclooxygenase inhibition and colorectal cancer.阿司匹林、环氧化酶抑制与结直肠癌
World J Gastrointest Pharmacol Ther. 2014 Feb 6;5(1):40-9. doi: 10.4292/wjgpt.v5.i1.40.
9
Baseline selenium status and effects of selenium and vitamin e supplementation on prostate cancer risk.基础硒状态和硒与维生素 E 补充对前列腺癌风险的影响。
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Aspirin and prostate cancer prevention.阿司匹林与前列腺癌预防
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用已证实的心血管疾病预防方法预防侵袭性前列腺癌。

Preventing aggressive prostate cancer with proven cardiovascular disease preventive methods.

作者信息

Moyad Mark A

机构信息

Department of Urology, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA.

出版信息

Asian J Androl. 2015 Nov-Dec;17(6):874-7; discussion 876. doi: 10.4103/1008-682X.156854.

DOI:10.4103/1008-682X.156854
PMID:26112486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4814969/
Abstract

Cardiovascular disease (CVD) has been the number one cause of death in the U.S. for 114 of the last 115 years. Risk factors for prostate cancer have primarily mirrored risk proven risk factors for CVD, especially aggressive disease. Obesity, dyslipidemia, glucose intolerance, metabolic syndrome, unhealthy dietary habits or caloric excess, lack of physical activity, and inflammation are just some of these shared risk factors. The evidence also suggests proven CVD preventive measures are identical to prostate cancer preventive measures, especially in regard to aggressive disease. Thus, apart from lifestyle measures that can encourage optimal heart and prostate health there are potentially several dietary supplements that need to be avoided in healthy men because they may also increase the risk of prostate cancer. However, there are also several low-cost, generic, safe in the appropriate individuals, and naturally derived agents that could reduce prostate cancer risk, and these can be discussed and remembered utilizing the acronym S.A.M. (statins, aspirin, and/or metformin).

摘要

在过去115年中的114年里,心血管疾病(CVD)一直是美国的头号死因。前列腺癌的危险因素主要反映了已证实的心血管疾病危险因素,尤其是侵袭性疾病的危险因素。肥胖、血脂异常、葡萄糖不耐受、代谢综合征、不健康的饮食习惯或热量过剩、缺乏体育活动以及炎症只是其中一些共同的危险因素。证据还表明,已证实的心血管疾病预防措施与前列腺癌预防措施相同,尤其是对于侵袭性疾病。因此,除了有助于促进心脏和前列腺健康的生活方式措施外,健康男性可能还需要避免几种膳食补充剂,因为它们也可能增加前列腺癌的风险。然而,也有几种低成本、普通、对适当个体安全且天然衍生的药物可以降低前列腺癌风险,这些可以用首字母缩写词S.A.M.(他汀类药物、阿司匹林和/或二甲双胍)来讨论和记忆。