Eriksson N E, Lindgren S B
Scand J Respir Dis. 1978 Feb;59(1):30-6.
The onset of action of three sympathomimetic drugs (rimiterol 0.2 mg, terbutaline 0.25 mg and isoprenaline 0.08 mg) administered by metered dose inhaler was compared in 12 asthmatics. In order to evaluate side effects of the drugs, a second dose of the aerosols, 8-10 times higher than the first one, was given after 30 min. The effects were measured in terms of VC, FEV1.0, PEF and heart rate. All the substances caused a significant increase in spirometric values within 1.5 min, the results with isoprenaline being slightly better than those with terbutaline. An increased heart rate was observed after the first dose of isoprenaline whereas no further increase was found after the higher dose. Two patients complained of palpitations, one after isoprenaline and one after rimiterol. No other side effects were recorded. It is concluded that there is a small, clinically insignificant, difference in the onset of action of isoprenaline compared with that of the selective beta2-stimulating aerosol, terbutaline.
对12名哮喘患者比较了通过定量吸入器给予的三种拟交感神经药物（利米特罗0.2毫克、特布他林0.25毫克和异丙肾上腺素0.08毫克）的起效时间。为了评估药物的副作用，30分钟后给予第二剂气雾剂，剂量比第一剂高8 - 10倍。通过肺活量（VC）、第一秒用力呼气量（FEV1.0）、呼气峰值流速（PEF）和心率来测量效果。所有药物在1.5分钟内均使肺功能测定值显著增加，异丙肾上腺素的结果略优于特布他林。首次给予异丙肾上腺素后观察到心率增加，而给予更高剂量后未发现进一步增加。两名患者抱怨有心悸，一名在使用异丙肾上腺素后，一名在使用利米特罗后。未记录到其他副作用。结论是，与选择性β2激动剂气雾剂特布他林相比，异丙肾上腺素的起效时间存在微小的、临床意义不大的差异。
