Lin Fan-Yu, Wu Hung-Chang, Cheng Kuo-Chen, Tung Chao-Ling, Chang Chi-Pei, Feng Yin-Hsun
Department of Internal Medicine, Chi-Mei Medical Center, Yong Kang, Tainan, Taiwan.
Int J Hematol. 2015 Sep;102(3):312-7. doi: 10.1007/s12185-015-1831-z. Epub 2015 Jun 27.
Adipokines play a role in carcinogenesis in a variety of malignancies. These findings were established with regard to serum adipokines and malignancies. However, the expression of adipokines in bone marrow fluid remains unclear, and an investigation of the correlation between bone marrow adipokines and hematological malignancy is needed. The present study was designed to detect adipokine concentrations, including adiponectin, leptin and resistin, in bone marrow interstitial fluid from patients with hematological malignancy and controlled counterparts. The correlations between adipokines, body mass index, clinical parameters, and hematological malignancy were assessed. A total of 80 bone marrow samples were assessed for values of adipokines, adiponectin, leptin and resistin. Patients with hematological malignancy had lower levels of adiponectin. Adiponectin from leukemia bone marrow expressed significantly low values. The adiponectin levels were inversely correlated with body mass index. In conclusion, adiponectin was decreased in bone marrow from patients with leukemia and negatively correlated with body mass index.
脂肪因子在多种恶性肿瘤的致癌过程中发挥作用。这些发现是关于血清脂肪因子与恶性肿瘤的。然而，脂肪因子在骨髓液中的表达仍不清楚，需要对骨髓脂肪因子与血液系统恶性肿瘤之间的相关性进行研究。本研究旨在检测血液系统恶性肿瘤患者和对照者骨髓间质液中脂肪因子的浓度，包括脂联素、瘦素和抵抗素。评估了脂肪因子、体重指数、临床参数与血液系统恶性肿瘤之间的相关性。共评估了80份骨髓样本的脂肪因子、脂联素、瘦素和抵抗素值。血液系统恶性肿瘤患者的脂联素水平较低。白血病骨髓中的脂联素表达值显著较低。脂联素水平与体重指数呈负相关。总之，白血病患者骨髓中的脂联素减少，且与体重指数呈负相关。
