Department of Radiology, Napa Solano Service Area, Kaiser Permanente Northern California, Vacaville, and Department of Radiology, University of California, Davis, CA.
Department of Obstetrics and Gynecology, University of Kentucky Medical Center, Lexington, KY.
Am J Obstet Gynecol. 2015 Nov;213(5):657-61, 657.e1. doi: 10.1016/j.ajog.2015.06.041. Epub 2015 Jun 23.
Ovarian cancer is among the most dreaded cancers since it is often found at a late stage where the opportunity for extended survival is poor. Ultrasound has been utilized in several ovarian cancer screening trials in asymptomatic women in order to detect ovarian cancer at early stages where survival rates are high. Efforts to improve screening for ovarian cancer are ongoing. While ovarian cancer screening in asymptomatic women is not recommended for clinical application currently, the care of women with adnexal masses found by ultrasound in clinical practice can benefit from close evaluation of the evidence obtained from large prospective ovarian cancer screening trials and by relating this evidence to recent advances in the understanding of different types of ovarian cancer. Post-menopausal women who have an adnexal mass discovered by ultrasound have a much higher risk of developing ovarian cancer than women with normal ultrasound. The preponderance of reported evidence indicates that ultrasound monitoring of an adnexal mass is safe, cost effective and can achieve an improved positive predictive value in detecting ovarian cancer when ovarian abnormalities resolve during surveillance. Proposals to arbitrarily discontinue ultrasound monitoring can negatively impact patient care and generate medical-legal actions, especially because there is no evidence to support safe discontinuation. In this review, we outline a rationale for continuing ultrasound surveillance of ovarian abnormalities.
卵巢癌是最令人恐惧的癌症之一,因为它通常在晚期才被发现,此时延长生存期的机会很差。超声已被用于几项无症状女性的卵巢癌筛查试验中,以在生存率较高的早期阶段发现卵巢癌。目前正在努力改进卵巢癌的筛查。虽然目前不建议将无症状女性的卵巢癌筛查用于临床应用,但对在临床实践中通过超声发现附件包块的女性进行密切评估,可以从大型前瞻性卵巢癌筛查试验中获得的证据中受益,并将该证据与理解不同类型卵巢癌的最新进展联系起来。经超声发现附件包块的绝经后妇女比超声正常的妇女发生卵巢癌的风险高得多。大多数报告的证据表明,当监测期间卵巢异常消退时,超声监测附件包块是安全的、具有成本效益的,并可以提高检测卵巢癌的阳性预测值。任意停止超声监测的建议可能会对患者护理产生负面影响,并引发医疗法律诉讼,特别是因为没有证据支持安全停止。在这篇综述中,我们概述了继续对卵巢异常进行超声监测的基本原理。