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1型和2型卵巢癌时代现存附件包块的超声监测:卵巢癌筛查试验的经验教训

Ultrasound Monitoring of Extant Adnexal Masses in the Era of Type 1 and Type 2 Ovarian Cancers: Lessons Learned From Ovarian Cancer Screening Trials.

作者信息

Ormsby Eleanor L, Pavlik Edward J, McGahan John P

机构信息

Department of Radiology, University of California Davis Medical Center, 4860 Y Street, Suite 3100, Sacramento, CA 95817, USA.

Department of Radiology, Kaiser Permanente Sacramento, 2025 Morse Ave, CA 95825, USA.

出版信息

Diagnostics (Basel). 2017 Apr 28;7(2):25. doi: 10.3390/diagnostics7020025.

DOI:10.3390/diagnostics7020025
PMID:28452952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5489945/
Abstract

Women that are positive for an ovarian abnormality in a clinical setting can have either a malignancy or a benign tumor with probability favoring the benign alternative. Accelerating the abnormality to surgery will result in a high number of unnecessary procedures that will place cost burdens on the individual and the health delivery system. Surveillance using serial ultrasonography is a reasonable alternative that can be used to discover if changes in the ovarian abnormality will occur that favor either a malignant or benign interpretation. Several ovarian cancer screening trials have had extensive experiences with changes in subclinical ovarian abnormalities in normal women that can define growth, stability or resolution and give some idea of the time frame over which changes occur. The present report examines these experiences and relates them to the current understanding of ovarian cancer ontology, presenting arguments related to the benefits of surveillance.

摘要

在临床环境中卵巢异常检测呈阳性的女性,其卵巢肿物可能是恶性肿瘤,也可能是良性肿瘤,且更有可能是良性的。将异常情况迅速推进至手术会导致大量不必要的手术操作,给个人和医疗系统带来成本负担。采用连续超声检查进行监测是一种合理的替代方法,可用于发现卵巢异常情况是否会出现有利于恶性或良性判断的变化。多项卵巢癌筛查试验在正常女性亚临床卵巢异常变化方面积累了丰富经验,这些变化可明确肿物的生长、稳定或消退情况,并能大致了解变化发生的时间框架。本报告审视了这些经验,并将其与当前对卵巢癌本体论的理解相关联,提出了有关监测益处的观点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0569/5489945/671dc22d7136/diagnostics-07-00025-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0569/5489945/355778f45a03/diagnostics-07-00025-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0569/5489945/f8a0699a001d/diagnostics-07-00025-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0569/5489945/2d69d0cf7298/diagnostics-07-00025-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0569/5489945/671dc22d7136/diagnostics-07-00025-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0569/5489945/355778f45a03/diagnostics-07-00025-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0569/5489945/f8a0699a001d/diagnostics-07-00025-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0569/5489945/2d69d0cf7298/diagnostics-07-00025-g003a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0569/5489945/671dc22d7136/diagnostics-07-00025-g004.jpg

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本文引用的文献

1
First International Consensus Report on Adnexal Masses: Management Recommendations.附件肿物的首份国际共识报告:管理建议
J Ultrasound Med. 2017 May;36(5):849-863. doi: 10.1002/jum.14197. Epub 2017 Mar 7.
2
Evaluation and Management of Ultrasonographically Detected Ovarian Tumors in Asymptomatic Women.无症状妇女超声检查发现的卵巢肿瘤的评估和管理。
Obstet Gynecol. 2016 May;127(5):848-858. doi: 10.1097/AOG.0000000000001384.
3
Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial.
英国卵巢癌筛查协作试验(UKCTOCS)中的卵巢癌筛查与死亡率:一项随机对照试验
Lancet. 2016 Mar 5;387(10022):945-956. doi: 10.1016/S0140-6736(15)01224-6. Epub 2015 Dec 17.
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Ultrasound follow up of an adnexal mass has the potential to save lives.附件包块的超声随访有可能拯救生命。
Am J Obstet Gynecol. 2015 Nov;213(5):657-61, 657.e1. doi: 10.1016/j.ajog.2015.06.041. Epub 2015 Jun 23.
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Cancer statistics, 2015.癌症统计数据,2015 年。
CA Cancer J Clin. 2015 Jan-Feb;65(1):5-29. doi: 10.3322/caac.21254. Epub 2015 Jan 5.
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Serial ultrasonographic evaluation of ovarian abnormalities with a morphology index.形态指数对卵巢异常的连续超声评估。
Gynecol Oncol. 2014 Oct;135(1):8-12. doi: 10.1016/j.ygyno.2014.07.091. Epub 2014 Jul 25.
7
Outcomes from ultrasound follow-up of small complex adnexal masses in women over 50.50岁以上女性附件区小复杂包块的超声随访结果。
Am J Obstet Gynecol. 2014 Dec;211(6):623.e1-7. doi: 10.1016/j.ajog.2014.07.044. Epub 2014 Jul 25.
8
Recent concepts of ovarian carcinogenesis: type I and type II.卵巢癌发生的最新概念:I型和II型。
Biomed Res Int. 2014;2014:934261. doi: 10.1155/2014/934261. Epub 2014 Apr 23.
9
Psychological morbidity associated with ovarian cancer screening: results from more than 23,000 women in the randomised trial of ovarian cancer screening (UKCTOCS).与卵巢癌筛查相关的心理疾病:来自卵巢癌筛查随机试验(英国卵巢癌筛查协作试验)中超过23000名女性的结果。
BJOG. 2014 Aug;121(9):1071-9. doi: 10.1111/1471-0528.12870. Epub 2014 May 28.
10
Transvaginal ultrasonography in ovarian cancer screening: current perspectives.经阴道超声检查在卵巢癌筛查中的应用现状
Int J Womens Health. 2013 Dec 20;6:25-33. doi: 10.2147/IJWH.S38347.