Ferencz A, Prinz G, Szalka A, Ban E
Central Municipal Hospital for Infectious Diseases, Budapest, Hungary.
Chemotherapy. 1989;35 Suppl 2:5-9. doi: 10.1159/000238731.
Two potent third-generation cephalosporins with similar antibacterial spectra but different pharmacokinetics were compared in patients suffering from septicemia due to different organismus. Sixty patients with a variety of underlying diseases were included in the study. They received either 2-4 g ceftriaxone (active ingredient of Rocephin) once a day or 2 g cefotaxime every 8 h for 10-15 days. Our data confirm that a single dose of 2 g ceftriaxone should be sufficient to treat septicemia.
对两种具有相似抗菌谱但药代动力学不同的强效第三代头孢菌素进行了比较，研究对象为因不同病原体导致败血症的患者。该研究纳入了60名患有各种基础疾病的患者。他们每天接受一次2 - 4克头孢曲松（罗氏芬的活性成分）治疗，或每8小时接受2克头孢噻肟治疗，疗程为10 - 15天。我们的数据证实，单剂量2克头孢曲松就足以治疗败血症。
