胃液对血凝块的溶解作用：一项体外研究。
Clot lysis by gastric juice: an in vitro study.
作者信息
Patchett S E, Enright H, Afdhal N, O'Connell W, O'Donoghue D P
机构信息
Dept of Gastroenterology, St Vincent's Hospital, Dublin, Ireland.
出版信息
Gut. 1989 Dec;30(12):1704-7. doi: 10.1136/gut.30.12.1704.
Abstract
Gastric juice from patients with peptic ulcer disease and from patients with no upper gastrointestinal abnormality was studied in order to assess its effect on a formed fibrin clot. In both groups of patients gastric juice caused a marked increase in fibrinolysis as evidenced by a shortening of the euglobulin clot lysis time. This plasmin mediated fibrinolytic activity was found to be heat labile and only present in an acid environment. Addition of tranexamic acid or sucralfate to gastric juice almost completely reversed this effect, whereas pepstatin was only partially effective. It is probable that acid dependent proteases other than pepsin are responsible for the marked fibrinolysis. The ulcer healing agent sucralfate might be useful in those patients at risk of bleeding or rebleeding from active peptic ulcer disease.
摘要
为了评估消化性溃疡病患者和无上消化道异常患者的胃液对已形成纤维蛋白凝块的影响，对其进行了研究。在两组患者中，胃液均导致纤维蛋白溶解显著增加，优球蛋白凝块溶解时间缩短证明了这一点。发现这种纤溶酶介导的纤维蛋白溶解活性对热不稳定，且仅存在于酸性环境中。向胃液中添加氨甲环酸或硫糖铝几乎完全逆转了这种作用，而胃蛋白酶抑制剂仅部分有效。除胃蛋白酶外，可能还有其他酸依赖性蛋白酶导致显著的纤维蛋白溶解。溃疡愈合剂硫糖铝可能对有活动性消化性溃疡病出血或再出血风险的患者有用。
相似文献
1
Clot lysis by gastric juice: an in vitro study.胃液对血凝块的溶解作用：一项体外研究。
Gut. 1989 Dec;30(12):1704-7. doi: 10.1136/gut.30.12.1704.
2
Pharmacological manipulation of gastric juice: thrombelastographic assessment and implications for treatment of gastrointestinal haemorrhage.胃液的药理学调控：血栓弹力图评估及其对胃肠道出血治疗的意义
Gut. 1995 Mar;36(3):358-62. doi: 10.1136/gut.36.3.358.
3
Sucralfate protects blood clots from peptic digestion by gastric juice in vitro.硫糖铝在体外可保护血凝块不被胃液消化。
Digestion. 2006;73(2-3):198-203. doi: 10.1159/000094529. Epub 2006 Jul 11.
4
Gastric fibrinolysis.胃纤维蛋白溶解
Thromb Diath Haemorrh. 1975 Nov 15;34(2):409-18.
5
6
Pepsins, peptic activity, and peptic inhibitors.胃蛋白酶、消化活性及消化抑制剂
J Clin Gastroenterol. 1981;3(Suppl 2):91-4.
7
Effects of sucralfate and its components on acid- and pepsin-induced damage to rat gastric epithelial cells.硫糖铝及其成分对酸和胃蛋白酶诱导的大鼠胃上皮细胞损伤的影响。
Jpn J Pharmacol. 1997 Sep;75(1):21-5. doi: 10.1254/jjp.75.21.
8
[Stressfulness of gastric juice].[胃液的应激性]
Biull Eksp Biol Med. 1981 Mar;91(3):300-3.
9
Are there indications for intravenous acid-inhibition in the prevention and treatment of upper GI bleeding?在预防和治疗上消化道出血方面，静脉使用抑酸剂是否有指征？
Scand J Gastroenterol Suppl. 2000(232):10-20.
10
Pepsin 5 in gastric juice: determination and relationship to the alkali-stable peptic activity.胃液中的胃蛋白酶5：测定及其与碱稳定的胃蛋白酶活性的关系。
Gut. 1979 Nov;20(11):977-82. doi: 10.1136/gut.20.11.977.
引用本文的文献
1
Turn over the new leaf of the treatment in peptic ulcer bleeding: a review of the literature.翻开消化性溃疡出血治疗的新篇章：文献综述
Therap Adv Gastroenterol. 2024 Sep 8;17:17562848241275318. doi: 10.1177/17562848241275318. eCollection 2024.
2
Tranexamic acid may be a useful pharmacotherapy for endoscopically resistant small bowel angiodysplasia.氨甲环酸可能是一种治疗内镜治疗抵抗性小肠血管扩张症的有效药物治疗方法。
World J Gastroenterol. 2023 Feb 21;29(7):1131-1138. doi: 10.3748/wjg.v29.i7.1131.
3
Aligned nanofibrous collagen membranes from fish swim bladder as a tough and acid-resistant suture for pH-regulated stomach perforation and tendon rupture.源自鱼鳔的排列纳米纤维胶原膜，作为一种坚韧且耐酸的缝线，用于pH调节的胃穿孔和肌腱断裂修复。
Biomater Res. 2022 Nov 8;26(1):60. doi: 10.1186/s40824-022-00306-1.
4
Development and Testing of Thrombolytics in Stroke.溶栓药物在中风治疗中的研发与测试。
J Stroke. 2021 Jan;23(1):12-36. doi: 10.5853/jos.2020.03349. Epub 2021 Jan 31.
5
Diagnosis and Management of Non-Variceal Gastrointestinal Hemorrhage: A Review of Current Guidelines and Future Perspectives.非静脉曲张性胃肠道出血的诊断与管理：当前指南及未来展望综述
J Clin Med. 2020 Feb 2;9(2):402. doi: 10.3390/jcm9020402.
6
ACVIM consensus statement: Support for rational administration of gastrointestinal protectants to dogs and cats.美国兽医内科学会共识声明：支持合理给犬猫使用胃肠道保护剂。
J Vet Intern Med. 2018 Nov;32(6):1823-1840. doi: 10.1111/jvim.15337. Epub 2018 Oct 31.
7
High-dose vs. Low-dose Proton Pump Inhibitors post-endoscopic hemostasis in patients with bleeding peptic ulcer. A meta-analysis and meta-regression analysis.高剂量与低剂量质子泵抑制剂用于消化性溃疡出血患者内镜止血后的疗效比较：一项荟萃分析和元回归分析
Turk J Gastroenterol. 2018 Jan;29(1):22-31. doi: 10.5152/tjg.2018.17143.
8
Medical management of gastrinoma in a cat.猫胃泌素瘤的药物治疗
JFMS Open Rep. 2016 Apr 25;2(1):2055116916646389. doi: 10.1177/2055116916646389. eCollection 2016 Jan-Jun.
9
Comparing intravenous and oral proton pump inhibitor therapy for bleeding peptic ulcers following endoscopic management: a systematic review and meta-analysis.内镜治疗后出血性消化性溃疡的静脉与口服质子泵抑制剂治疗比较：一项系统评价与荟萃分析
Br J Clin Pharmacol. 2017 Aug;83(8):1619-1635. doi: 10.1111/bcp.13258. Epub 2017 Mar 21.
10
Effective and safe proton pump inhibitor therapy in acid-related diseases - A position paper addressing benefits and potential harms of acid suppression.质子泵抑制剂在酸相关性疾病中的有效与安全治疗——一份探讨抑酸益处及潜在危害的立场文件
BMC Med. 2016 Nov 9;14(1):179. doi: 10.1186/s12916-016-0718-z.
本文引用的文献
1
Comparison of surgical and medical management of bleeding peptic ulcers.出血性消化性溃疡的手术治疗与内科治疗比较
Br Med J (Clin Res Ed). 1982 Feb 20;284(6315):548-50. doi: 10.1136/bmj.284.6315.548.
2
Cimetidine and tranexamic acid in the treatment of acute upper-gastrointestinal-tract bleeding.西咪替丁与氨甲环酸治疗急性上消化道出血
N Engl J Med. 1983 Jun 30;308(26):1571-5. doi: 10.1056/NEJM198306303082606.
3
Upper gastrointestinal bleeding.上消化道出血
Ann Surg. 1972 May;175(5):771-82. doi: 10.1097/00000658-197205000-00017.
4
Gastric fibrinolysis. A possible aetiological link with peptic ulcer.胃纤维蛋白溶解。与消化性溃疡可能的病因学联系。
Lancet. 1967 Jun 17;1(7503):1300-2. doi: 10.1016/s0140-6736(67)91594-2.
5
Continuous intravenous infusions of famotidine maintain high intragastric pH in duodenal ulcer.持续静脉输注法莫替丁可维持十二指肠溃疡患者较高的胃内pH值。
Gut. 1988 Apr;29(4):453-7. doi: 10.1136/gut.29.4.453.
6
Tranexamic acid as an aid to reducing blood transfusion requirements in gastric and duodenal bleeding.氨甲环酸有助于减少胃十二指肠出血时的输血量。
Br Med J (Clin Res Ed). 1987 Jan 3;294(6563):7-10. doi: 10.1136/bmj.294.6563.7.
7
A study of the factors influencing mortality rates from gastrointestinal haemorrhage.一项关于影响胃肠道出血死亡率因素的研究。
Q J Med. 1976 Oct;45(180):533-50.
8
Tranexamic acid and upper gastrointestinal haemorrhage--a double-blind trial.氨甲环酸与上消化道出血——一项双盲试验
Gut. 1976 Sep;17(9):729-34. doi: 10.1136/gut.17.9.729.
9
Fibrinolytic activity in gastric venous blood. A comparison between normal and diseased stomachs.胃静脉血中的纤溶活性。正常胃与患病胃的比较。
Gastroenterology. 1979 Mar;76(3):509-14.
10
Experience with antipeptic agents.抗溃疡药物的使用经验。
Scand J Gastroenterol Suppl. 1979;55:121-3.
Zotero 插件