氨甲环酸有助于减少胃十二指肠出血时的输血量。
Tranexamic acid as an aid to reducing blood transfusion requirements in gastric and duodenal bleeding.
作者信息
von Holstein C C, Eriksson S B, Källén R
出版信息
Br Med J (Clin Res Ed). 1987 Jan 3;294(6563):7-10. doi: 10.1136/bmj.294.6563.7.
Abstract
A prospective randomised double blind study examined the effect of the antifibrinolytic drug tranexamic acid compared with placebo in 154 patients bleeding from verified benign lesions in the stomach or duodenum or both. Three out of 72 patients receiving tranexamic acid underwent emergency surgery compared with 15 out of 82 given placebo (p = 0.010). Nineteen patients receiving placebo rebled during their admission as compared with 10 in the active treatment group (p = 0.097). Blood transfusion requirements were significantly reduced by tranexamic acid (p = 0.018). Side effects occurred in six patients, of which an uncomplicated deep venous thrombosis was the most severe. Tranexamic acid reduces the blood transfusion requirement and need for emergency surgery in patients bleeding from a benign gastric or duodenal lesion.
摘要
一项前瞻性随机双盲研究，比较了抗纤溶药物氨甲环酸与安慰剂对154例经证实的胃或十二指肠或两者良性病变出血患者的疗效。接受氨甲环酸治疗的72例患者中有3例接受了急诊手术，而给予安慰剂的82例患者中有15例接受了急诊手术（p = 0.010）。19例接受安慰剂治疗的患者在住院期间再次出血，而积极治疗组为10例（p = 0.097）。氨甲环酸显著降低了输血需求（p = 0.018）。6例患者出现副作用，其中最严重的是无并发症的深静脉血栓形成。氨甲环酸可减少良性胃或十二指肠病变出血患者的输血需求和急诊手术需求。
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