Ershadi Sara, Noori Narjes, Dashipoor Alireza, Ghasemi Marzieh, Shamsa Nahid
Department of Obstetrics and Gynecology, Zahedan University of Medical Sciences, Zahedan, Iran.
Pregnancy Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
J Family Med Prim Care. 2022 May;11(5):2162-2166. doi: 10.4103/jfmpc.jfmpc_1817_21. Epub 2022 May 14.
Implantation failure is a major problem in reproductive medicine, and despite the various methods described for treatment, there is little consensus on the most effective method. This study was conducted to investigate the effect of intrauterine injection of platelet-rich plasma (PRP) on the pregnancy rate of patients with a history of implantation failure in the fertilization (IVF) cycle.
In this study, women attending the infertility clinic of Ali ibn Abi Taleb Hospital, who had a history of implantation failure and were candidates for frozen embryo transfer (FET), were examined in Zahedan (Iran) in 2019. The patients were divided into two groups of PRP recipients and the control group. IVF was performed routinely, and in the PRP-receiving group, an intrauterine injection was given 48 h before embryo transfer (ET). The number of gestational sacs, the rate of implantation, the frequency of chemical and clinical pregnancies as well as the frequency of abortion were compared in the two groups. The collected data were analyzed by the SPSS software version 21.
Ninety patients with a history of implantation failure participated in the study, and finally, the information of 85 patients was studied. The frequency of chemical pregnancy was 40% in the experimental group, 27% in the control group, and regarding clinical pregnancy, 33% in the experimental group and 24% in the control group, but there was no significant difference between the two groups. The rate of implantation, the mean thickness of the endometrium, and the frequency of abortion did not differ significantly between the two groups.
In patients with endometrial thickness greater than 8 mm with a history of recurrent implantation failure, intrauterine injection of PRP had no effect on the fertility outcome.
着床失败是生殖医学中的一个主要问题，尽管描述了各种治疗方法，但对于最有效的方法几乎没有共识。本研究旨在探讨宫腔内注射富血小板血浆（PRP）对体外受精（IVF）周期中有着床失败史患者妊娠率的影响。
在本研究中，2019年在扎黑丹（伊朗）对阿里·伊本·阿比·塔利卜医院不孕不育门诊中有着床失败史且为冻融胚胎移植（FET）候选者的女性进行了检查。将患者分为PRP接受组和对照组。常规进行IVF，在PRP接受组中，于胚胎移植（ET）前48小时进行宫腔内注射。比较两组的妊娠囊数量、着床率、生化妊娠和临床妊娠频率以及流产频率。收集的数据采用SPSS 21版软件进行分析。
90例有着床失败史的患者参与了研究，最终对85例患者的信息进行了研究。实验组生化妊娠频率为40%，对照组为27%；关于临床妊娠，实验组为33%，对照组为24%，但两组之间无显著差异。两组的着床率、子宫内膜平均厚度和流产频率无显著差异。
对于子宫内膜厚度大于8mm且有反复着床失败史的患者，宫腔内注射PRP对生育结局无影响。
