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Oxidation of cysteine 117 stimulates constitutive activation of the type Iα cGMP-dependent protein kinase.
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Examining a role for PKG Iα oxidation in the pathogenesis of cardiovascular dysfunction during diet-induced obesity.
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本文引用的文献
1
Crystal structure of the cGMP-dependent protein kinase II leucine zipper and Rab11b protein complex reveals molecular details of G-kinase-specific interactions.
J Biol Chem. 2014 Sep 12;289(37):25393-403. doi: 10.1074/jbc.M114.575894. Epub 2014 Jul 28.
2
Oxidant-induced activation of cGMP-dependent protein kinase Iα mediates neuropathic pain after peripheral nerve injury.
Antioxid Redox Signal. 2014 Oct 1;21(10):1504-15. doi: 10.1089/ars.2013.5585. Epub 2014 Mar 5.
3
Gαq signalling: the new and the old.
Cell Signal. 2014 May;26(5):833-48. doi: 10.1016/j.cellsig.2014.01.010. Epub 2014 Jan 17.
4
Protein kinase G oxidation is a major cause of injury during sepsis.
Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9909-13. doi: 10.1073/pnas.1301026110. Epub 2013 May 28.
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PKA: lessons learned after twenty years.
Biochim Biophys Acta. 2013 Jul;1834(7):1271-8. doi: 10.1016/j.bbapap.2013.03.007. Epub 2013 Mar 25.
6
H₂O₂ lowers the cytosolic Ca²⁺ concentration via activation of cGMP-dependent protein kinase Iα.
Free Radic Biol Med. 2012 Oct 15;53(8):1574-83. doi: 10.1016/j.freeradbiomed.2012.08.011. Epub 2012 Aug 15.
7
Nitroglycerin fails to lower blood pressure in redox-dead Cys42Ser PKG1α knock-in mouse.
Circulation. 2012 Jul 17;126(3):287-95. doi: 10.1161/CIRCULATIONAHA.112.101287. Epub 2012 Jun 9.
8
Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension.
Nat Med. 2012 Jan 15;18(2):286-90. doi: 10.1038/nm.2603.
9
H2O2-induced dilation in human coronary arterioles: role of protein kinase G dimerization and large-conductance Ca2+-activated K+ channel activation.
Circ Res. 2012 Feb 3;110(3):471-80. doi: 10.1161/CIRCRESAHA.111.258871. Epub 2011 Dec 8.
10
Novel roles of cAMP/cGMP-dependent signaling in platelets.
J Thromb Haemost. 2012 Feb;10(2):167-76. doi: 10.1111/j.1538-7836.2011.04576.x.
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