基于四种体外检测方法，比较室内灰尘和污染土壤中砷的生物可给性。
Comparison of arsenic bioaccessibility in housedust and contaminated soils based on four in vitro assays.
机构信息
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210046, People's Republic of China.
Centre for Environmental Risk Assessment and Remediation, University of South Australia, Mawson Lakes, South Australia 5095, Australia.
出版信息
Sci Total Environ. 2015 Nov 1;532:803-11. doi: 10.1016/j.scitotenv.2015.06.060. Epub 2015 Jun 29.
Few studies have assessed As bioaccessibility in housedust using different in vitro assays and compared to those in contaminated soils. We determined As bioaccessibility in 24 housedust samples (4.48-38.2 mg kg(-1)) using SBRC, IVG, DIN, and PBET assays and they averaged 73, 68, 53, and 48% in the gastric phase and 26, 46, 55 and 43% in the intestinal phase of the 4 assays. The corresponding As bioaccessibility in 34 As-contaminated soils (22-6899 mg kg(-1)) were 34, 25, 22, and 22% in the gastric phase and 18, 19, 21, and 20% in the intestinal phase, which was 1.5-2.7 fold lower than those in housedust possibly due to differences in contamination sources and properties. Based on the gastric phase of SBRC assay, As bioaccessibility was 44-96% in housedust and 2.3-80% in soils. Variation in As bioaccessibility among assays was similar for housedust and soils, with SBRC assay providing the highest bioaccessibility in gastric phase. In intestinal phase, dissolved As was probably adsorbed onto precipitated iron oxides, causing a sharp decrease in As bioaccessibility by SBRC assay. Unlike SBRC assay, gastric constituents (pepsin, mucin, phosphate, and citrate) in other 3 assays inhibited As adsorption and/or enhanced As dissolution, leading to greater As bioaccessibility. The greater As bioaccessibility in housedust than soil suggests the potential of greater health risk from As exposure to housedust than soil.
很少有研究使用不同的体外检测方法评估房屋灰尘中砷的生物可给性，并将其与污染土壤中的情况进行比较。我们使用 SBRC、IVG、DIN 和 PBET 测定了 24 个房屋灰尘样本（4.48-38.2mg/kg）中的砷生物可给性，其在胃阶段的平均值分别为 73%、68%、53%和 48%，在肠阶段的平均值分别为 26%、46%、55%和 43%。在 34 个砷污染土壤样本（22-6899mg/kg）中，相应的砷生物可给性在胃阶段分别为 34%、25%、22%和 22%，在肠阶段分别为 18%、19%、21%和 20%，这可能是由于污染来源和性质的差异，其在胃阶段的生物可给性比房屋灰尘低 1.5-2.7 倍。根据 SBRC 试验的胃阶段，房屋灰尘中的砷生物可给性为 44-96%，土壤中的砷生物可给性为 2.3-80%。房屋灰尘和土壤中各测定方法的砷生物可给性差异相似，SBRC 测定法在胃阶段提供了最高的生物可给性。在肠阶段，溶解的砷可能被沉淀的氧化铁吸附，导致 SBRC 测定法的砷生物可给性急剧下降。与 SBRC 测定法不同，其他 3 种测定法中的胃成分（胃蛋白酶、黏蛋白、磷酸盐和柠檬酸盐）抑制了砷的吸附和/或增强了砷的溶解，从而导致更高的砷生物可给性。房屋灰尘中的砷生物可给性大于土壤，这表明与土壤相比，房屋灰尘中砷暴露对健康的潜在风险更大。
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