Chen Shida, Zhang Xiulan
From the Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, China.
Asia Pac J Ophthalmol (Phila). 2015 Jul-Aug;4(4):236-41. doi: 10.1097/APO.0000000000000122.
Glaucoma is a group of progressive optic neuropathies, characterized by the degeneration of retinal ganglion cells related to the level of intraocular pressure and other factors. The exact pathogenesis of glaucoma is not known, and current therapeutic options are not sufficient to prevent or recover vision loss in glaucoma patients. Functional, repeatable, and easy-to-use animal models are therefore needed. Because of their inherent advantages, rodent animals, including mice and rats, have been widely developed as models to study various aspects of glaucoma and to evaluate possible novel therapies. However, no single model has been shown to emulate all aspects of glaucoma. In this review, we discuss currently available rodent animal models of glaucoma, their strengths and weaknesses, and the possible implications for current glaucoma research.
青光眼是一组进行性视神经病变，其特征是视网膜神经节细胞的退化与眼压水平及其他因素有关。青光眼的确切发病机制尚不清楚，目前的治疗方法不足以预防或恢复青光眼患者的视力丧失。因此，需要功能性、可重复且易于使用的动物模型。由于其固有的优势，包括小鼠和大鼠在内的啮齿动物已被广泛开发为研究青光眼各个方面和评估可能的新疗法的模型。然而，没有一个单一的模型能模拟青光眼的所有方面。在这篇综述中，我们讨论了目前可用的啮齿动物青光眼模型、它们的优缺点以及对当前青光眼研究的可能影响。
