Gerstenecker Adam, Duff Kevin, Meneses Karen, Fiveash John B, Nabors Louis B, Triebel Kristen L
1Department of Neurology,Division of Neuropsychology,UAB,Birmingham,Alabama.
2Department of Neurology,University of Utah,Salt Lake City,Utah.
J Int Neuropsychol Soc. 2015 Jul;21(6):412-8. doi: 10.1017/S1355617715000478. Epub 2015 Jul 7.
To examine the association between reasoning through medical treatment decisions and cognition in a sample of patients with brain metastasis. The association between reasoning and cognition was examined using data from 41 patients with diagnosed brain metastasis. All diagnoses were made by a board-certified radiation oncologist and were verified histologically. In total, 41 demographically matched, cognitively healthy controls were also included to aid in classifying patients with brain metastasis according to reasoning status (i.e., intact or impaired). Results indicate that measures of episodic memory and processing speed were associated with reasoning. Using these two predictors, actuarial equations were constructed that can be used to help screen for impaired reasoning ability in patients' with brain metastasis. The equations presented in this study have clinical significance as they can be used to help identify patients at risk for possessing a diminished ability to reason through medical treatment decisions and, thus, are in need of a more comprehensive evaluation of their medical decision-making capacity.
在一组脑转移患者样本中，研究通过医疗决策进行推理与认知之间的关联。使用41例已确诊脑转移患者的数据，研究推理与认知之间的关联。所有诊断均由具备专业资格认证的放射肿瘤学家做出，并经组织学验证。总共还纳入了41名在人口统计学上匹配的、认知健康的对照者，以帮助根据推理状态（即完整或受损）对脑转移患者进行分类。结果表明，情景记忆和处理速度的测量指标与推理有关。利用这两个预测指标构建了精算方程，可用于帮助筛查脑转移患者的推理能力受损情况。本研究中提出的方程具有临床意义，因为它们可用于帮助识别那些在通过医疗决策进行推理方面能力下降、因此需要对其医疗决策能力进行更全面评估的患者。
