稳定型冠状动脉疾病患者的血管内皮功能

Vascular endothelial function of patients with stable coronary artery disease.

作者信息

Wang Zhe, Yang Xinchun, Cai Jun, Shi Hui, Zhong Guangzhen, Chi Hongjie

机构信息

Zhe Wang, MD. Heart Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

Xinchun Yang, MD. Heart Center, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

出版信息

Pak J Med Sci. 2015;31(3):538-42. doi: 10.12669/pjms.313.6892.

DOI:10.12669/pjms.313.6892

PMID:26150839

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4485266/

Abstract

OBJECTIVES

To evaluate vascular endothelial function and contributing factors in coronary heart disease (CHD) patients.

METHODS

One hundred twenty six CHD outpatients were randomly recruited. Reactive hyperemia index (RHI) <1.67 indicates endothelial dysfunction. Correlation between RHI and different biochemical parameters was evaluated.

RESULTS

RHI in patients receiving statins treatment was significantly higher than patients without statins treatment (P<0.05). RHI in patients with more than 3 risk factors for CHD was also markedly lower than that in patients with ≤2 risk factors (P<0.05). Patients with lesions at several branches of coronary artery had a markedly lower RHI when compared with those with coronary lesions at a single branch (P<0.05). For patients without statins treatment, RHI increased significantly after statins treatment for 1 month (P=0.01). In patients with endothelial dysfunction, FBG, HbA1C, hs-CRP and Hcy were significantly higher than those in patients with normal endothelial function (P<0.05 for all). Smokers with CHD had a remarkably lower RHI when compared with non-smokers (P<0.05).

CONCLUSIONS

Smoking, FBG, HbA1C, Hcy and hs-CRP are significantly associated with endothelial dysfunction. Endothelial dysfunction is also related to the numbers of risk factors for CHD, degree of coronary lesions and statins. Statins treatment may significantly improve the endothelial function of CHD patients.

摘要

目的

评估冠心病（CHD）患者的血管内皮功能及相关影响因素。

方法

随机招募126例冠心病门诊患者。反应性充血指数（RHI）<1.67表明存在内皮功能障碍。评估RHI与不同生化参数之间的相关性。

结果

接受他汀类药物治疗的患者的RHI显著高于未接受他汀类药物治疗的患者（P<0.05）。具有3个以上冠心病危险因素的患者的RHI也明显低于具有≤2个危险因素的患者（P<0.05）。冠状动脉多个分支有病变的患者的RHI明显低于冠状动脉单个分支有病变的患者（P<0.05）。对于未接受他汀类药物治疗的患者，他汀类药物治疗1个月后RHI显著升高（P=0.01）。在内皮功能障碍患者中，空腹血糖（FBG）、糖化血红蛋白（HbA1C）、高敏C反应蛋白（hs-CRP）和同型半胱氨酸（Hcy）显著高于内皮功能正常的患者（均P<0.05）。患有冠心病的吸烟者的RHI明显低于不吸烟者（P<0.05）。