化合物331通过上调miR-494和下调细胞分裂周期蛋白20（CDC20）来选择性地诱导胶质瘤细胞死亡。
Compound 331 selectively induces glioma cell death by upregulating miR-494 and downregulating CDC20.
作者信息
Zhang Lei, Niu Tianhui, Huang Yafei, Zhu Haichuan, Zhong Wu, Lin Jian, Zhang Yan
机构信息
State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, 100871, China.
1] Synthetic and Functional Biomolecules Center, College of Chemistry and Molecular Engineering, Peking University, Beijing, China [2] Aviation Medicine Research Laboratory, The General Hospital of the Air Force, Beijing, China.
出版信息
Sci Rep. 2015 Jul 8;5:12003. doi: 10.1038/srep12003.
Malignant gliomas are the most common malignant tumors in the central nervous system (CNS). Up to date, the prognosis of glioma is still very poor, effective therapy with less side-effect is very necessary. Herein, we identify a compound named as "331" selectively induced cell death in glioma cells but not in astrocytes. Compound 331 upregulated miR-494 and downregulated CDC20 in glioma cells but not in astrocytes. These results suggest that compound 331 could be a potential drug selectively targeting glioma cells through upregulating miR-494 and downregulating CDC20.
恶性胶质瘤是中枢神经系统（CNS）中最常见的恶性肿瘤。迄今为止，胶质瘤的预后仍然很差，因此非常需要副作用较小的有效治疗方法。在此，我们鉴定出一种名为“331”的化合物，它能选择性地诱导胶质瘤细胞死亡，而对星形胶质细胞无此作用。化合物331在胶质瘤细胞中上调miR-494并下调CDC20，但在星形胶质细胞中无此现象。这些结果表明，化合物331可能是一种潜在药物，通过上调miR-494和下调CDC20来选择性地靶向胶质瘤细胞。
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