Brower Jeffrey V, Clark Paul A, Lyon Will, Kuo John S
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Neurochem Int. 2014 Nov;77:68-77. doi: 10.1016/j.neuint.2014.06.002. Epub 2014 Jun 14.
MicroRNAs represent an abundant class of endogenously expressed 18-25 nucleotide non-coding RNA molecules that function to silence gene expression through a process of post-transcriptional modification. They exhibit varied and widespread functions during normal development and tissue homeostasis, and accordingly their dysregulation plays major roles in many cancer types. Gliomas are cancers arising from the central nervous system. The most malignant and common glioma is glioblastoma multiforme (GBM), and even with aggressive treatment (surgical resection, chemotherapy, and radiation), average patient survival remains less than 2 years. In this review we will summarize the current findings regarding microRNAs in GBM and the biological and clinical implications of this data.
微小RNA是一类丰富的内源性表达的18 - 25个核苷酸的非编码RNA分子，其通过转录后修饰过程使基因表达沉默。它们在正常发育和组织稳态过程中发挥着多样且广泛的功能，因此其失调在许多癌症类型中起主要作用。胶质瘤是起源于中枢神经系统的癌症。最恶性且常见的胶质瘤是多形性胶质母细胞瘤（GBM），即使采用积极治疗（手术切除、化疗和放疗），患者的平均生存期仍不足2年。在本综述中，我们将总结关于GBM中微小RNA的当前研究结果以及这些数据的生物学和临床意义。
