Kar K, Nath A, Bajpai R, Dutta G P, Vishwakarma R A
Division of Pharmacology, Central Drug Research Institute, Lucknow, India.
J Ethnopharmacol. 1989 Dec;27(3):297-305. doi: 10.1016/0378-8741(89)90004-4.
Pharmacological studies on alpha/beta arteether (a 30:70 mixture of isomers), a potential drug for the treatment of cerebral malaria, were carried out in experimental animals by giving the drug in arachis oil suspension. The compound appears to be devoid of significant pharmacological activity on the central nervous, cardiovascular and urinary systems. It lacks an anti-inflammatory response in rats up to 50 mg/kg intramuscularly but at 50-200 mg/kg it has some antianaphylactic potential.
对α/β蒿甲醚(一种异构体比例为30:70的混合物)进行了药理学研究,它是一种治疗脑型疟疾的潜在药物,通过在花生油混悬液中给药,在实验动物身上进行研究。该化合物在中枢神经、心血管和泌尿系统似乎没有明显的药理活性。大鼠肌肉注射高达50mg/kg时,它缺乏抗炎反应,但在50-200mg/kg时有一定的抗过敏潜力。