Tawfik A F, Bishop S J, Ayalp A, el-Feraly F S
Department of Pharmaceutics and Microbiology, College of Pharmacy, King Saud University, Saudi Arabia.
Int J Immunopharmacol. 1990;12(4):385-9. doi: 10.1016/0192-0561(90)90019-j.
Artemisinin (Qinghaosu) is a potent antimalarial sesquiterpene lactone isolated from the Chinese herb Artemisia annua. Arteether, a potent semisynthetic analogue of dihydroartemisinin is being developed by the World Health Organization as the artemisinin derivative of choice for the treatment of malaria. All three agents in doses of 400 and 600 mg/kg body weight were found to exhibit marked suppression of humoral responses, as measured by the hemolytic plaque assay, with arteether being the most potent. These agents did not alter the delayed-type hypersensitivity response to sheep erythrocytes at the same dose levels. In addition, all three agents were found not to possess any anti-inflammatory activity when tested on carrageenan-induced oedema. These results indicated that these agents have a selective immunosuppressive activity. They did not exhibit immunostimulating activity in contrast to what has been reported for sodium artesunate.
青蒿素（青蒿琥酯）是一种从中国草药黄花蒿中分离出的强效抗疟倍半萜内酯。蒿甲醚是双氢青蒿素的一种强效半合成类似物，世界卫生组织正在将其开发为治疗疟疾的首选青蒿素衍生物。通过溶血空斑试验测定发现，所有三种药物在剂量为400和600mg/kg体重时均表现出对体液反应的显著抑制，其中蒿甲醚作用最强。在相同剂量水平下，这些药物并未改变对绵羊红细胞的迟发型超敏反应。此外，在角叉菜胶诱导的水肿试验中发现，所有三种药物均不具有任何抗炎活性。这些结果表明，这些药物具有选择性免疫抑制活性。与青蒿琥酯钠的报道相反，它们未表现出免疫刺激活性。
