Tripathi R, Dutta G P, Vishwakarma R A
Central Drug Research Institute, Lucknow, India.
Am J Trop Med Hyg. 1990 Dec;43(6):571-5. doi: 10.4269/ajtmh.1990.43.571.
A new sesquiterpene lactone alpha/beta arteether (a 30:70 mixture of enantiomers), which possesses very high blood schizontocidal activity, has been evaluated for gametocytocidal/sporontocidal action against Plasmodium cynomolgi B infection in the rhesus monkey. This paper reports gametocytocidal action of this new antimalarial drug at 2.5-5 mg/kg (single im dose) against P. cynomologi B as shown by the complete absence of mosquito infectivity. No sporontocidal action was demonstrable in the vector at a dose of up to 20-50 mg/kg im.
一种新的倍半萜内酯α/β蒿乙醚（对映体的30:70混合物），具有非常高的血液裂殖体杀灭活性，已针对恒河猴体内食蟹猴疟原虫B感染的配子体杀灭/子孢子杀灭作用进行了评估。本文报告了这种新型抗疟药物在2.5-5毫克/千克（单次肌肉注射剂量）时对食蟹猴疟原虫B的配子体杀灭作用，表现为完全没有蚊子感染性。在高达20-50毫克/千克肌肉注射剂量下，未在媒介昆虫中显示出子孢子杀灭作用。
