Kim Sang-Kyun, Nam SeJin, Jang Hyunchul, Kim Anna, Lee Jeong-Ju
Mibyeong Research Center, Korea Institute of Oriental Medicine, Daejeon, South Korea.
Biomedical Knowledge Engineering Laboratory, Seoul National University, Seoul, South Korea.
BMC Complement Altern Med. 2015 Jul 9;15:218. doi: 10.1186/s12906-015-0758-5.
In traditional medicine, there has been a great deal of research on the effects exhibited by medicinal materials. To study the effects, resources that can systematically describe the chemical compounds in medicinal materials are necessary. In recent years, numerous databases on medicinal materials and constituent compounds have been constructed. However, because these databases provide differing information and the sources of such information are unclear or difficult to verify, it is difficult to decide which database to use. Moreover, there is much overlapping information. The aim of this study was to construct a database of medicinal materials and chemical compounds in Northeast Asian traditional medicine (TM-MC), for which medicinal materials are listed in the Korean, Chinese, and Japanese pharmacopoeias and information on the compound names of medicinal materials can easily be confirmed online.
To provide information on the chemical compounds of medicinal materials, chromatography articles from MEDLINE and PubMed Central were searched. After chemical compounds of medicinal materials were extracted by manually investigating the full-text of articles, a database of information on about 14,000 compounds from 536 medicinal materials was built. The database also provides links to the articles from which each medicinal material and chemical compound were extracted.
TM-MC database provides information on medicinal materials and their chemical compounds from chromatography articles in MEDLINE and PubMed Central. Researchers can easily check relevant information through the links to articles.
在传统医学中，对药材所展现的功效已有大量研究。为研究这些功效，需要能够系统描述药材中化学成分的资源。近年来，已构建了众多关于药材及其成分化合物的数据库。然而，由于这些数据库提供的信息各异，且此类信息的来源不明确或难以核实，因此难以决定使用哪个数据库。此外，存在大量重叠信息。本研究的目的是构建一个东北亚传统医学药材与化合物数据库（TM-MC），该数据库列出了韩国、中国和日本药典中的药材，且药材化合物名称的信息可轻松在网上确认。
为提供药材化学成分的信息，检索了MEDLINE和PubMed Central上的色谱学文章。通过人工查阅文章全文提取药材的化学成分后，建立了一个包含536种药材约14000种化合物信息的数据库。该数据库还提供了每种药材和化合物所提取自的文章的链接。
TM-MC数据库提供了MEDLINE和PubMed Central上色谱学文章中有关药材及其化合物的信息。研究人员可通过文章链接轻松查阅相关信息。
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