Pöntinen P J
Acta Anaesthesiol Scand. 1978;22(2):145-53. doi: 10.1111/j.1399-6576.1978.tb01291.x.
The adrenergic beta-receptor blocking drug, alprenolol, was given together with atropine to 15 patients during neurolept analgesia (NLA) in order to prevent adrenaline-induced cardiac arrhythmias. Four patients operated on without adrenergic beta-receptor blockade formed the control group. Three of them developed tachyarrhythmias, ventricular tachycardia, multifocal ventricular extrasystoles and supraventricular tachycardia. All these arrhythmias were terminated by the adrenergic beta-receptor blocking drug, propranolol. The fourth patient developed a temporary sinus tachycardia which did not require any treatment. The adrenergic beta-receptor blockade induced a slight increase in pulse rate with almost no change in arterial blood pressure. The incidence of arrhythmias due to adrenaline infiltration was much less in this group. There was one supraventricular tachycardia and scattered ventricular extrasystoles in two other patients. NLA alone does not protect the heart against adrenaline-induced arrhythmias. It does, however, seem to be compatible with an adrenergic beta-receptor blockade, which in turn provides partial protection against adrenaline-induced arrhythmias. The occasionally developing arrhythmias can then be terminated with specific adrenergic beta blockers.
在神经安定镇痛（NLA）期间，将肾上腺素能β受体阻滞剂阿普洛尔与阿托品一起给予15例患者，以预防肾上腺素引起的心律失常。4例未接受肾上腺素能β受体阻滞的患者作为对照组接受手术。其中3例出现快速心律失常，包括室性心动过速、多源性室性期前收缩和室上性心动过速。所有这些心律失常均被肾上腺素能β受体阻滞剂普萘洛尔终止。第4例患者出现短暂性窦性心动过速，无需任何治疗。肾上腺素能β受体阻滞使脉搏率略有增加，而动脉血压几乎没有变化。该组中因肾上腺素浸润引起的心律失常发生率要低得多。另外2例患者出现1次室上性心动过速和散在的室性期前收缩。单独使用NLA并不能保护心脏免受肾上腺素引起的心律失常的影响。然而，它似乎与肾上腺素能β受体阻滞相容，而肾上腺素能β受体阻滞反过来又能部分预防肾上腺素引起的心律失常。偶尔出现的心律失常随后可用特定的肾上腺素能β受体阻滞剂终止。
