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通过检测脐带血中抗原特异性免疫球蛋白E水平评估宫内致敏情况。

Evaluation of in utero sensitization by screening antigen-specific immunoglobulin E levels in umbilical cord blood.

作者信息

Gürbüz Tamay, Karakol Burcu, Önal Zehra Esra, Tabak Yonca, Nuhoğlu Çağatay, Ceran Ömer

机构信息

Department of Pediatrics, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey. Head of the Department: Çağatay Nuhoğlu MD, Assoc. Prof.

出版信息

Postepy Dermatol Alergol. 2015 Jun;32(3):184-8. doi: 10.5114/pdia.2015.48051. Epub 2015 Jun 15.

Abstract

INTRODUCTION

The incidence of asthma and atopic reactions is increasing worldwide. Previous reports have suggested that maternal exposure to allergens during pregnancy may have potential effects on allergic sensitization in infants.

AIM

To evaluate the effects of maternal exposure to environmental allergens during pregnancy on in-utero sensitization.

MATERIAL AND METHODS

Two hundred mothers and their infants were analyzed in this cross-sectional study. Mothers were given a questionnaire that had a series of questions to evaluate the maternal allergic status and environmental exposures during pregnancy. Plasma specific immunoglobulin E (IgE) levels to pets, grass, food (nuts) of all mothers and their infants were analyzed by an immune-enzymatic assay.

RESULTS

There was no significant correlation between plasma specific IgE positivity in mothers, with regard to keeping indoor domestic pets, living in grass habitat, eating nuts in diet. A significant correlation was found between specific IgE presence in mothers and allergic reactions; however, there was no correlation between plasma specific IgE positivity of mothers and infants.

CONCLUSIONS

We concluded that prenatal maternal sensitivity to environmental allergens could not be evaluated as a predictive factor for in-utero sensitization.

摘要

引言

全球范围内哮喘和特应性反应的发病率正在上升。先前的报告表明,孕期母亲接触过敏原可能对婴儿的过敏致敏有潜在影响。

目的

评估孕期母亲接触环境过敏原对宫内致敏的影响。

材料与方法

在这项横断面研究中分析了200对母婴。母亲们填写了一份问卷,其中有一系列问题来评估母亲的过敏状态和孕期的环境暴露情况。通过免疫酶测定法分析所有母亲及其婴儿针对宠物、草、食物(坚果)的血浆特异性免疫球蛋白E(IgE)水平。

结果

母亲血浆特异性IgE阳性与饲养室内宠物、生活在草地环境、饮食中食用坚果之间无显著相关性。母亲体内特异性IgE的存在与过敏反应之间存在显著相关性;然而,母亲和婴儿的血浆特异性IgE阳性之间无相关性。

结论

我们得出结论,产前母亲对环境过敏原的敏感性不能作为宫内致敏的预测因素进行评估。

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