Department of Prevention of Envirnomental Hazards and Allergoloy, Warsaw Medical University, Warsaw, Poland.
Eur J Med Res. 2009 Dec 7;14 Suppl 4(Suppl 4):233-6. doi: 10.1186/2047-783x-14-s4-233.
The present study was conducted to learn whether the perinatal and environmental factors could influence the total and antigen-specific IgE levels in umbilical cord blood. Retrospective data were obtained from 173 mother-infant pairs. Total and specific (for children's food, wheat/grass and house dust mite-HDM) cord blood IgE levels were determined using the immunoassay test. The total cord blood IgE was between 0.0-23.08 IU/ml (mean 0.55 +/-2.07 IU/ml; median 0.16 IU/ml). Total IgE levels were significantly higher in boys compared with girls (OR=2.2; P=0.007), and in newborns with complicated pregnancy (OR=2.7; P=0.003). A greater number of siblings correlated with increases in the total cord blood IgE (P<0.02). We detected specific IgE in 34 newborns (40 positive tests). A long-standing contact with a cat during pregnancy decreased the specific IgE level for wheat/grass (OR=3.2; P<0.07) and for children's food (OR=5.0; P<0.04), and the contact with a dog decreased the specific-IgE for wheat/grass (OR=0.3; P<0.05). Exposure to tobacco smoke correlated with the positive specific IgE toward house dust mite (OR=4.7; P=0.005).
本研究旨在探讨围产期和环境因素是否会影响脐带血中总 IgE 和特异性 IgE 水平。本研究回顾性分析了 173 对母婴。采用免疫测定法检测脐带血总 IgE 和特异性 IgE（针对儿童食物、小麦/草和屋尘螨-HDM）。脐带血总 IgE 水平为 0.0-23.08 IU/ml（均值 0.55 +/-2.07 IU/ml；中位数 0.16 IU/ml）。与女孩相比，男孩的总 IgE 水平显著更高（OR=2.2；P=0.007），且在妊娠复杂的新生儿中更高（OR=2.7；P=0.003）。兄弟姐妹数量的增加与总脐带血 IgE 水平的增加相关（P<0.02）。我们在 34 名新生儿中检测到特异性 IgE（40 项阳性检测）。妊娠期间与猫的长期接触可降低对小麦/草（OR=3.2；P<0.07）和儿童食物（OR=5.0；P<0.04）的特异性 IgE 水平，而与狗的接触可降低对小麦/草的特异性 IgE 水平（OR=0.3；P<0.05）。接触烟草烟雾与屋尘螨阳性特异性 IgE 相关（OR=4.7；P=0.005）。
