Bønnelykke Klaus, Pipper Christian Bressen, Bisgaard Hans
Danish Pediatric Asthma Center, Department of Pediatrics, Copenhagen University Hospital, Copenhagen, Denmark.
J Allergy Clin Immunol. 2008 Mar;121(3):646-51. doi: 10.1016/j.jaci.2007.12.1149.
Intrauterine sensitization has been suggested to play a role in the development of atopic disease in children, and this has led to current guidelines recommending allergen avoidance during pregnancy.
To investigate the relevance of allergen-specific IgE in cord blood to sensitization in early infancy and the origin of such IgE.
Inhalant and food allergen-specific IgE in cord blood was analyzed and compared with specific IgE in infant blood at 6 months of age and in parental blood. Cord blood IgA was measured to detect maternal blood contamination of cord blood.
Allergen-specific IgE, primarily against inhalant allergens, was detected in 14% of cord blood samples. However, corresponding specific IgE was not found in infant blood at 6 months of age. Specific IgE in cord blood completely matched specific IgE in maternal blood with respect to allergen specificity, level of specific IgE, and ratio of total IgE/specific IgE. Finally, there was a correlation between specific IgE and IgA in cord blood.
Allergen-specific IgE in cord blood does not reflect intrauterine sensitization but seems to be the result of transfer of maternal IgE to the fetus.
子宫内致敏被认为在儿童过敏性疾病的发展中起作用，这导致了当前指南建议孕期避免接触过敏原。
研究脐血中过敏原特异性IgE与婴儿早期致敏的相关性以及此类IgE的来源。
分析脐血中吸入性和食物过敏原特异性IgE，并与6月龄婴儿血液及父母血液中的特异性IgE进行比较。检测脐血IgA以检测脐血是否受母体血液污染。
14%的脐血样本中检测到过敏原特异性IgE，主要针对吸入性过敏原。然而，6月龄婴儿血液中未发现相应的特异性IgE。脐血中的特异性IgE在过敏原特异性、特异性IgE水平以及总IgE/特异性IgE比值方面与母体血液中的特异性IgE完全匹配。最后，脐血中特异性IgE与IgA之间存在相关性。
脐血中的过敏原特异性IgE并不反映子宫内致敏，而似乎是母体IgE转移至胎儿的结果。
