Nair Sharmila, Diamond Michael S
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA; Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, MO 63110, USA.
Curr Opin Immunol. 2015 Oct;36:47-53. doi: 10.1016/j.coi.2015.06.011. Epub 2015 Jul 8.
The innate immune system mediates protection against neurotropic viruses that replicate in the central nervous system (CNS). Virus infection within specific cells of the CNS triggers activation of several families of pattern recognition receptors including Toll-like receptors, retinoic acid-inducible gene I like receptors, nucleotide-binding oligomerization domain-like receptors, and cytosolic DNA sensors. In this review, we highlight recent advances in our understanding of how cell-intrinsic host defenses within the CNS modulate infection of different DNA and RNA viruses.
先天性免疫系统介导对在中枢神经系统(CNS)中复制的嗜神经病毒的保护作用。中枢神经系统特定细胞内的病毒感染会触发多种模式识别受体家族的激活,包括Toll样受体、视黄酸诱导基因I样受体、核苷酸结合寡聚化结构域样受体和胞质DNA传感器。在本综述中,我们重点介绍了我们对中枢神经系统内细胞内在宿主防御如何调节不同DNA和RNA病毒感染的最新认识进展。