Mizumoto Shuji, Yamada Shuhei, Sugahara Kazuyuki
Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Department of Pathobiochemistry, Faculty of Pharmacy, Meijo University, Nagoya, Japan; Laboratory of Proteoglycan Signaling and Therapeutics, Graduate School of Life Science, Hokkaido University, Sapporo, Japan.
Curr Opin Struct Biol. 2015 Oct;34:35-42. doi: 10.1016/j.sbi.2015.06.004. Epub 2015 Jul 9.
Recent functional studies on chondroitin sulfate-dermatan sulfate (CS-DS) demonstrated its indispensable roles in various biological events including brain development and cancer. CS-DS proteoglycans exert their physiological activity through interactions with specific proteins including growth factors, cell surface receptors, and matrix proteins. The characterization of these interactions is essential for regulating the biological functions of CS-DS proteoglycans. Although amino acid sequences on the bioactive proteins required for these interactions have already been elucidated, the specific saccharide sequences involved in the binding of CS-DS to target proteins have not yet been sufficiently identified. In this review, recent findings are described on the interaction between CS-DS and some proteins which are especially involved in the central nervous system and cancer development/metastasis.
最近关于硫酸软骨素-硫酸皮肤素（CS-DS）的功能研究表明，其在包括脑发育和癌症在内的各种生物学事件中发挥着不可或缺的作用。CS-DS蛋白聚糖通过与特定蛋白质（包括生长因子、细胞表面受体和基质蛋白）相互作用来发挥其生理活性。这些相互作用的特征对于调节CS-DS蛋白聚糖的生物学功能至关重要。尽管已经阐明了这些相互作用所需的生物活性蛋白上的氨基酸序列，但参与CS-DS与靶蛋白结合的特定糖序列尚未得到充分鉴定。在这篇综述中，描述了关于CS-DS与一些特别参与中枢神经系统和癌症发展/转移的蛋白质之间相互作用的最新发现。
