Institute of Biology of Karelian Research Centre Russian Academy of Sciences, 185910 Petrozavodsk, Russian Federation.
Children`s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Programs Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland; Folkhälsan Research Center, Helsinki, Finland; Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland.
Autoimmun Rev. 2015 Nov;14(11):1029-37. doi: 10.1016/j.autrev.2015.07.005. Epub 2015 Jul 8.
Rheumatoid arthritis (RA) is a polygenic disease characterized by autoimmunity and systemic inflammation with progressive impairment of joints that results in lifelong disability and increased mortality. Early diagnosis and therapeutic intervention or treatment can prevent severe disease manifestations in patients suffering from RA. The use of appropriate predictive biomarkers may improve the efficiency of RA therapy. The general aim of this review is to highlight the most recent findings on miRNAs expression profiles in RA patients and to discuss their potential as new biomarkers for diagnostic purposes. The current literature demonstrates that a variety of miRNAs is frequently dysregulated in RA patients. To date, the majority of miRNAs have been found to be overexpressed during the natural course of RA. MiR-16, miR-146a/b, miR-150, miR-155, and miR-223 described here were shown to be overexpressed at the systemic level: in both the periphery and RA joints. Circulating peripheral blood miRNAs, especially miR-16, miR-21, miR-24, miR-26a, miR-125a-5p, miR-125b, miR-126-3p, miR-223, and miR-451, which are elevated in the plasma or serum, are considered to be the most promising non-invasive biomarkers for the detection of RA.
类风湿关节炎（RA）是一种多基因疾病，其特征为自身免疫和全身炎症，伴有进行性关节损伤，导致终身残疾和死亡率增加。早期诊断和治疗干预或治疗可以预防 RA 患者的严重疾病表现。适当的预测生物标志物的使用可能会提高 RA 治疗的效率。本综述的总体目的是强调 RA 患者中 miRNA 表达谱的最新发现，并讨论其作为诊断目的的新生物标志物的潜力。目前的文献表明，RA 患者中存在多种 miRNA 表达失调。迄今为止，大多数 miRNA 在 RA 的自然病程中被发现过度表达。这里描述的 miR-16、miR-146a/b、miR-150、miR-155 和 miR-223 被证明在全身水平（外周和 RA 关节）过度表达。循环外周血 miRNA，特别是 miR-16、miR-21、miR-24、miR-26a、miR-125a-5p、miR-125b、miR-126-3p、miR-223 和 miR-451，在血浆或血清中升高，被认为是检测 RA 的最有前途的非侵入性生物标志物。
