乙型肝炎病毒和丁型肝炎病毒宿主嗜性的决定因素。
Determinants of hepatitis B and delta virus host tropism.
作者信息
Winer Benjamin Y, Ploss Alexander
机构信息
Department of Molecular Biology, Princeton University, 110 Lewis Thomas Laboratory, Washington Road, Princeton, NJ 11 08544-101, USA.
Department of Molecular Biology, Princeton University, 110 Lewis Thomas Laboratory, Washington Road, Princeton, NJ 11 08544-101, USA.
出版信息
Curr Opin Virol. 2015 Aug;13:109-16. doi: 10.1016/j.coviro.2015.06.004. Epub 2015 Jul 8.
Abstract
Hepatitis B virus (HBV) infections are a global health problem afflicting approximately 360 million patients. Of these individuals, 15-20 million are co-infected with hepatitis delta virus (HDV). Progress toward curative therapies has been impeded by the highly restricted host tropism of HBV, which is limited to productive infections in humans and chimpanzees. Here, we will discuss different approaches that have been taken to study HBV and HDV infections in vivo. The development of transgenic and humanized mice has lead to deeper insights into HBV pathogenesis. An improved understanding of the determinants governing HBV and HDV species tropism will aid in the construction of a small animal model with inheritable susceptible to HBV/HDV.
摘要
乙型肝炎病毒（HBV）感染是一个全球性的健康问题，困扰着约3.6亿患者。在这些个体中，1500万至2000万人同时感染了丁型肝炎病毒（HDV）。由于HBV高度受限的宿主嗜性，仅限于在人类和黑猩猩中产生有生产性的感染，这阻碍了治愈性疗法的进展。在这里，我们将讨论在体内研究HBV和HDV感染所采用的不同方法。转基因和人源化小鼠的发展使人们对HBV发病机制有了更深入的了解。更好地理解控制HBV和HDV物种嗜性的决定因素将有助于构建对HBV/HDV具有遗传性易感性的小动物模型。
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