Yoshioka Eriko, Yamaguchi Masahiko, Shiraishi Atsushi, Kono Tomoko, Ohta Kiyohiko, Ohashi Yuichi
Department of Ophthalmology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan.
Department of Ophthalmology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan; Department of Stem Cell Biology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan.
Am J Ophthalmol. 2015 Oct;160(4):685-692.e1. doi: 10.1016/j.ajo.2015.06.028. Epub 2015 Jul 9.
To determine the relationship between eyelid pressure during blinking and the fluorescein staining of the cornea and conjunctiva in dry eye patients.
Cross-sectional prospective study.
The pressure of the upper and lower eyelids was measured with a specially designed blepahro-tensiometer in 130 eyes of 65 dry eye patients (D group) and in 58 eyes of 31 normal controls (N group). The correlations between the location and degree of ocular surface staining scores and the eyelid pressure were calculated for the D group.
The pressures of the upper and lower eyelids were significantly higher in the D group than in the N group (upper P < .0001, lower P = .0040). The lower eyelid pressure was significantly correlated with the ocular surface staining scores for the inferior cornea (r = 0.19, P = .0307) and conjunctiva (r = 0.19, P = .0252).
The significant correlation between the eyelid pressure and the ocular surface staining suggests that mechanical friction on the ocular surface by the eyelids may be one of the factors that affects the fluorescein staining of the inferior ocular surface.
确定干眼患者眨眼时眼睑压力与角膜和结膜荧光素染色之间的关系。
横断面前瞻性研究。
使用特制的眼睑张力计测量65例干眼患者（D组）的130只眼以及31例正常对照者（N组）的58只眼的上下眼睑压力。计算D组眼表染色评分的位置和程度与眼睑压力之间的相关性。
D组上下眼睑压力显著高于N组（上睑P <.0001，下睑P =.0040）。下睑压力与下角膜（r = 0.19，P =.0307）和结膜（r = 0.19，P =.0252）的眼表染色评分显著相关。
眼睑压力与眼表染色之间的显著相关性表明，眼睑对眼表的机械摩擦可能是影响下眼表荧光素染色的因素之一。
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