Bora Emre, Walterfang Mark, Velakoulis Dennis
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia.
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia.
Behav Brain Res. 2015 Oct 1;292:515-20. doi: 10.1016/j.bbr.2015.07.012. Epub 2015 Jul 9.
Non-motor symptoms of Parkinson's disease (PD) include cognitive deficits and impairment in the recognition of emotions. Recently, a number of studies have investigated theory of mind (ToM) deficits in PD. In this meta-analysis of 18 studies, the ToM performance of 487 non-demented individuals with Parkinson's disease (PD) was compared with 459 healthy controls. Meta-regression analyses were conducted to investigate the relationship between ToM deficits and demographical and clinical features in PD, including medication, stage of the illness and neurocognition. PD was associated with significant ToM impairment (d = 0.83) in both verbal and visual tasks. In individual task analyses, PD patients performed worse than controls in both faux pas recognition (d = 0.55) and reading the mind from the eyes (d = 0.67) tests. Severity of ToM impairment was significantly associated with cognitive impairment. Impairments in social cognitive abilities, including ToM, may be important contributors to the functional impairments observed in PD.
帕金森病（PD）的非运动症状包括认知缺陷和情绪识别障碍。最近，一些研究调查了帕金森病患者的心理理论（ToM）缺陷。在这项对18项研究的荟萃分析中，将487名非痴呆帕金森病（PD）患者的心理理论表现与459名健康对照者进行了比较。进行了元回归分析，以研究帕金森病患者心理理论缺陷与人口统计学和临床特征之间的关系，包括用药情况、疾病阶段和神经认知。在言语和视觉任务中，帕金森病均与显著的心理理论损伤（d = 0.83）相关。在个体任务分析中，帕金森病患者在失言识别（d = 0.55）和眼神读心（d = 0.67）测试中的表现均比对照组差。心理理论损伤的严重程度与认知损伤显著相关。包括心理理论在内的社会认知能力损伤可能是帕金森病中观察到的功能损伤的重要原因。
