Atmaca Murad, Yildirim Hanefi, Yilmaz Seda, Caglar Neslihan, Mermi Osman, Gurok M Gurkan, Kekilli Yasemin, Turkcapar Hakan
a Department of Psychiatry , School of Medicine, Firat University , Elazig , Turkey.
b Department of Radiology , School of Medicine, Firat University , Elazig , Turkey.
Int J Psychiatry Clin Pract. 2015;19(4):285-9. doi: 10.3109/13651501.2015.1072220. Epub 2015 Sep 18.
In the present study, we examined the effects of cognitive behavioral therapy (CBT) on the hippocampal neurochemistry in patients with obsessive-compulsive disorder (OCD).
Twelve patients with OCD and same number of healthy controls were included into the study. Neurochemical variables of the hippocampus were measured before and after the CBT treatment in the patient group.
At baseline, the patients with OCD had significantly lower ratio of N-acetyl-l-aspartate/choline (NAA/CHO) compared with that of healthy control subjects. When comparing pre-treatment results of the patient group with those of post-treatment ones using paired t-test, we found that NAA/CHO ratio increased from 2.47 ± 0.64 to 3.66 ± 0.88, with a statisical significance.
The findings may implicate that CBT increases the level of NAA which is a marker of neuronal integrity.
在本研究中，我们探讨了认知行为疗法（CBT）对强迫症（OCD）患者海马神经化学的影响。
12名强迫症患者和相同数量的健康对照者纳入本研究。对患者组在CBT治疗前后测量海马的神经化学变量。
在基线时，强迫症患者的N-乙酰-L-天冬氨酸/胆碱（NAA/CHO）比值显著低于健康对照者。当使用配对t检验比较患者组治疗前与治疗后的结果时，我们发现NAA/CHO比值从2.47±0.64增加到3.66±0.88，具有统计学意义。
这些发现可能意味着CBT提高了作为神经元完整性标志物的NAA水平。
