Morselli P L, Zarifian E
Ciba Found Symp. 1979(74):115-39. doi: 10.1002/9780470720578.ch8.
The possible clinical significance of plasma level monitoring of psychotropic drugs in psychotic patients is described. In particular, data obtained with children and 'resistant' psychotic patients are presented. The results in children indicate the existence of a good relationship between side-effects and haloperidol plasma levels as well as between adverse effects and chlorimipramine plasma levels. Furthermore, an age effect on haloperidol clearance could be shown. Relationship between haloperidol and chlorimipramine concentration and effects could be observed for tics and enuresis respectively but not for psychotic reactions. Data in adult patients illustrate on the one hand possible causes of variability in plasma levels of haloperidol and, on the other hand, the fact that poor bioavailability is not the cause of lack of response in 'resistant' schizophrenic patients.
描述了精神药物血浆水平监测在精神病患者中的潜在临床意义。特别介绍了儿童和“难治性”精神病患者的数据。儿童的数据表明，副作用与氟哌啶醇血浆水平之间以及不良反应与氯米帕明血浆水平之间存在良好的关系。此外，还发现年龄对氟哌啶醇清除率有影响。分别观察到氟哌啶醇和氯米帕明浓度与抽动症和遗尿症之间的关系，但未观察到与精神病反应之间的关系。成年患者的数据一方面说明了氟哌啶醇血浆水平变异性的可能原因，另一方面说明了生物利用度差不是“难治性”精神分裂症患者无反应的原因。
