Kocher R
Eur Neurol. 1976;14(6):458-64. doi: 10.1159/000114773.
The results of long experience in the treatment of chronic and severe pains resistant to ordinary therapy with psychotropic drugs are reported. Out of 103 impatients with chronic and severe pains caused by neurological conditions, who were treated with a combination of thymoleptics and neuroleptics, 82 (approx. 82%) showed marked improvement. These encouraging results are compared with others published in this field. The pharmacological basis of this good action is briefly discussed, also the advantages of the use of psychotropic drugs, especially of the combination of thymoleptics and neuroleptics. A dosage schedule for in- and outpatients has been established, using imipramine (Tofranil) or chlorimipramine (Anafranil), and haloperidol (Haldol).
报告了长期使用精神药物治疗对普通疗法耐药的慢性和重度疼痛的经验结果。在103例因神经疾病引起慢性和重度疼痛的住院患者中，使用抗抑郁药和抗精神病药联合治疗，82例（约82%）有显著改善。将这些令人鼓舞的结果与该领域发表的其他结果进行了比较。简要讨论了这种良好作用的药理学基础，以及使用精神药物，特别是抗抑郁药和抗精神病药联合使用的优点。已制定了住院和门诊患者的用药方案，使用丙咪嗪（托弗尼尔）或氯米帕明（安拿芬尼）以及氟哌啶醇（哈多力）。
