Liang Feng, Terrada Celine, Ducos de Lahitte Ghislaine, Quartier Pierre, Lehoang Phuc, Thorne Jennifer E, Bodaghi Bahram
a Department of Ophthalmology , University of Paris VI, Pitié-Salpêtrière Hospital , Paris , France .
b Unit of Immuno-Hematology and Pediatric Rheumatology , Necker-Enfants Malades Hospital , Paris , France .
Ocul Immunol Inflamm. 2016 Aug;24(4):386-91. doi: 10.3109/09273948.2015.1012297. Epub 2015 Jul 14.
In juvenile idiopathic arthritis (JIA)-associated uveitis complicated by foveal serous retinal detachment (FSRD), we documented the relationship between best corrected visual acuity (BCVA), level of anterior chamber flare and OCT features.
Nine children (15 eyes) with FSRD were identified among 38 children with JIA-associated maculopathy. Outcome measures included BCVA, ocular inflammatory activity quantified by laser flare photometry and the macular profile analyzed by OCT.
The diagnosis of FSRD led to intensification of the treatment using subtenon's injection of triamcinolone or systemic immunomodulatory therapy. The improvement of BCVA at presentation (0.46 logMAR) was significant at 36 months follow-up (0.15 logMAR). The resolution of FSRD along with visual improvement (p = 0.0032) correlated with improvement in anterior chamber flare (p = 0.01).
FSRD is a complication of chronic JIA-associated uveitis that responds well to intensification of immunomodulation. Visual improvement is correlated with FSRD resolution and with flare photometry values.
在合并中心凹浆液性视网膜脱离（FSRD）的幼年特发性关节炎（JIA）相关性葡萄膜炎中，我们记录了最佳矫正视力（BCVA）、前房炎症程度与光学相干断层扫描（OCT）特征之间的关系。
在38例患有JIA相关性黄斑病变的儿童中，确定了9例（15只眼）患有FSRD的儿童。观察指标包括BCVA、通过激光散射光度法量化的眼部炎症活动以及通过OCT分析的黄斑情况。
FSRD的诊断导致使用球周注射曲安奈德或全身免疫调节治疗加强。就诊时的BCVA（0.46 logMAR）在36个月随访时（0.15 logMAR）有显著改善。FSRD的消退以及视力改善（p = 0.0032）与前房炎症程度改善（p = 0.01）相关。
FSRD是慢性JIA相关性葡萄膜炎的一种并发症，对免疫调节加强反应良好。视力改善与FSRD消退以及散射光度测量值相关。
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