de Boer Joke, Steijaert Arjen, van den Bor Rutger, Stellato Rebecca, Ossewaarde-van Norel Jeannette
Department of Ophthalmology, University Medical Center Utrecht , Utrecht , The Netherlands and.
Ocul Immunol Inflamm. 2015 Feb;23(1):67-73. doi: 10.3109/09273948.2013.871566. Epub 2014 Jan 10.
To investigate the development of macular edema (ME) in relation to the duration of uveitis and visual outcome in uveitis associated with juvenile idiopathic arthritis (JIA).
Sixty-one patients with JIA-uveitis (116 eyes) were investigated by Cirrus OCT for macular thickness. The relation between macular thickness and time interval since onset of uveitis and best corrected visual acuity (BCVA) was analyzed by linear mixed effect models.
Duration of follow-up showed significant positive linear relation with central macular thickness. The central macular thickness showed a significant linear relation with BCVA, but not with disease activity. Thirteen patients developed ME (central field thickness >304.4 µm) after a mean time interval of 11.6 years. Thirteen patients had macular thinning after a significant longer interval of uveitis compared to patients with normal or thickened macula.
Duration of JIA-uveitis is positively correlated with the development of ME, compromising the visual acuity.
研究与青少年特发性关节炎（JIA）相关的葡萄膜炎中黄斑水肿（ME）的发生与葡萄膜炎病程及视力转归的关系。
采用Cirrus OCT对61例JIA-葡萄膜炎患者（116只眼）的黄斑厚度进行检测。采用线性混合效应模型分析黄斑厚度与葡萄膜炎发病后的时间间隔及最佳矫正视力（BCVA）之间的关系。
随访时间与中心黄斑厚度呈显著正线性关系。中心黄斑厚度与BCVA呈显著线性关系，但与疾病活动度无关。13例患者在平均11.6年的时间间隔后发生ME（中心视野厚度>304.4µm）。与黄斑正常或增厚的患者相比，13例患者在葡萄膜炎发作间隔明显更长时间后出现黄斑变薄。
JIA-葡萄膜炎的病程与ME的发生呈正相关，会损害视力。
