Angioni Stefano, Cela Vito, Sedda Federica, Stochino Loi Emanuela, Cofelice Vito, Pontis Alessandro, Melis Gian Benedetto
a Division of Gynecology and Obstetrics, Department of Surgical Sciences , University of Cagliari , Cagliari , Italy .
b Division of Gynecology and Obstetrics, Department of Surgical Sciences , University of Pisa , Italy , and.
Gynecol Endocrinol. 2015;31(8):595-8. doi: 10.3109/09513590.2015.1062868. Epub 2015 Jul 14.
Infertility is a common problem in patients with endometriosis and the involved mechanisms are still not completely known. The management of infertility in endometriosis patients includes surgery as well as assisted reproductive technology. Laparoscopic surgery has shown better results in infertility patients with endometriosis in comparison to laparotomy procedures. Laparoscopic surgery has proposed benefits in both minimal to moderate diseases. However, while there may be some benefits with severe diseases, there is still not enough evidence to recommend laparoscopic surgery as the recommended surgery when the main goal is to obtain fertility. We performed a MEDLINE search for articles on fertility in women with deep infiltrating endometriosis (DIE) published between 1990 and April 2015 using the following keywords: "endometriosis", "deep infiltrative endometriosis", "infertility", "fertility after surgery", "laparoscopy surgery", "laparotomy", "pregnancy", "fertility outcome", "bladder endometriosis", and "ureteral endometriosis". The aim of this review was to analyze the results of available clinical studies (randomized controlled or not controlled studies; retrospective cohort studies; or case-control and prospective studies) and guidelines on surgical treatment of infertile endometriosis patients, and pregnancy outcomes after surgery.
不孕症是子宫内膜异位症患者的常见问题,其相关机制仍不完全清楚。子宫内膜异位症患者不孕症的治疗方法包括手术以及辅助生殖技术。与开腹手术相比,腹腔镜手术在子宫内膜异位症不孕症患者中显示出更好的效果。腹腔镜手术对轻度至中度疾病均有一定益处。然而,对于重度疾病,虽然可能有一些益处,但仍没有足够的证据推荐将腹腔镜手术作为以获得生育能力为主要目标时的首选手术。我们使用以下关键词在MEDLINE上检索了1990年至2015年4月期间发表的关于深部浸润性子宫内膜异位症(DIE)女性生育能力的文章:“子宫内膜异位症”、“深部浸润性子宫内膜异位症”、“不孕症”、“手术后生育能力”、“腹腔镜手术”、“开腹手术”、“妊娠”、“生育结局”、“膀胱子宫内膜异位症”和“输尿管子宫内膜异位症”。本综述的目的是分析现有临床研究(随机对照或非对照研究、回顾性队列研究、病例对照和前瞻性研究)的结果以及关于子宫内膜异位症不孕症患者手术治疗的指南和手术后的妊娠结局。