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腹腔镜下部分膀胱切除术治疗深部子宫内膜异位症后的生育结局:来自两个专家中心的回顾性分析及文献综述

Fertility outcomes after laparoscopic partial bladder resection for deep endometriosis: Retrospective analysis from two expert centres and review of the literature.

作者信息

Nyangoh Timoh Krystel, Ballester Marcos, Bendifallah Sofiane, Fauconnier Arnaud, Darai Emile

机构信息

Department of Obstetrics and Gynecology, Tenon Hospital, AP-HP, Paris, University Pierre et Marie Curie, Paris 6, France.

Department of Obstetrics and Gynecology, Tenon Hospital, AP-HP, Paris, University Pierre et Marie Curie, Paris 6, France; GRC6-UPMC, Centre expert en Endométriose (C3E), France; UMR_S938 University Pierre et Marie Curie Paris, France.

出版信息

Eur J Obstet Gynecol Reprod Biol. 2018 Jan;220:12-17. doi: 10.1016/j.ejogrb.2017.10.031. Epub 2017 Oct 31.

Abstract

OBJECTIVE

To evaluate fertility outcomes after laparoscopic partial bladder resection in women with bladder endometriosis and to review the literature.

STUDY DESIGN

A retrospective study conducted at two tertiary referral centres -Tenon University Hospital and Poissy University Hospital (Canadian Task Force Classification Level II-2)-from July 2006 to November 2015. Patients with bladder endometriosis who underwent either laparoscopic partial bladder resection (PBR) alone for those without posterior endometriotic lesions (PBR group) or both laparoscopic PBR and associated posterior deep infiltrating endometriosis (DIE) resection (PBR-PDIE group) were included. Pregnancy and live birth rates according to prior infertility, and associated posterior DIE resection were analysed.

RESULTS

Thirty-four patients were included; 15 in the PBR group and 19 in the PBR-PDIE group. The median age (range) was 31 years (25-37), Seventeen patients (50%) had prior infertility. The median follow-up after bladder resection was 60.6 months (12-116). Overall, of the 25 (73.5%) patients who wished to conceive, 17 (68%) achieved pregnancies resulting in a live birth rate of 76.4%. Among the 17 patients with prior infertility, nine (52.9%) conceived. Overall, eight patients (53.3%) in the PBR group conceived and nine (47.3%) in the PBR-PDIE group (difference not significant).

CONCLUSION

The present study demonstrates that laparoscopic PBR results in a high pregnancy rate in patients with prior infertility as well as in those with associated posterior DIE suggesting that surgery could be an acceptable alternative to first-line assisted reproductive technology.

摘要

目的

评估膀胱子宫内膜异位症女性患者行腹腔镜部分膀胱切除术后的生育结局并进行文献复习。

研究设计

一项回顾性研究,于2006年7月至2015年11月在两家三级转诊中心——特农大学医院和普瓦西大学医院(加拿大工作组分类II-2级)开展。纳入膀胱子宫内膜异位症患者,其中未合并后位子宫内膜异位病变的患者单纯接受腹腔镜部分膀胱切除术(PBR组),合并后位深部浸润性子宫内膜异位症(DIE)的患者接受腹腔镜PBR联合相关后位DIE切除术(PBR-PDIE组)。分析根据既往不孕情况及相关后位DIE切除术的妊娠和活产率。

结果

共纳入34例患者,PBR组15例,PBR-PDIE组19例。中位年龄(范围)为31岁(25-37岁),17例患者(50%)既往不孕。膀胱切除术后的中位随访时间为60.6个月(12-116个月)。总体而言,25例(73.5%)希望受孕的患者中,17例(68%)成功妊娠,活产率为76.4%。17例既往不孕的患者中,9例(52.9%)成功受孕。总体而言,PBR组8例患者(53.3%)受孕,PBR-PDIE组9例患者(47.3%)受孕(差异无统计学意义)。

结论

本研究表明,腹腔镜PBR在既往不孕患者以及合并后位DIE的患者中均有较高的妊娠率,提示手术可能是一线辅助生殖技术的可接受替代方案。

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