Feghali Edwin, Etrusco Andrea, Haydamous Joe, Ayed Amal, Laganà Antonio Simone, Chiantera Vito, Vitale Salvatore Giovanni, Angioni Stefano, Stabile Guglielmo, Sleiman Zaki
Department of Obstetrics and Gynecology, Lebanese American University Medical Center, Beirut 1100, Lebanon.
Unit of Gynecologic Oncology, ARNAS "Civico-Di Cristina-Benfratelli", Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, 90127 Palermo, Italy.
J Pers Med. 2023 Apr 24;13(5):716. doi: 10.3390/jpm13050716.
Adenomyosis and congenital uterine anomalies (CUAs) can compromise reproductive potential and may coexist in the same patient, especially in cases of infertility. This review (CRD42022382850) aims to evaluate the published cases of concurrent adenomyosis and syndromic and nonsyndromic CUAs. A literature search for suitable articles published in the English language was performed using the following databases from inception to 30 November 2022: MEDLINE, EMBASE, Global Health, the Cochrane Library, Health Technology Assessment Database, and Web of Science. Articles including both CUAs and adenomyosis, with data about their potential relationship, were included. The literature search retrieved 14 articles that met the purpose of this review and summarized the most recent findings regarding the concurrent diagnosis of adenomyosis and CUAs. Adenomyosis can be found in both syndromic and nonsyndromic CUAs, and may arise from several etiologies. The hypothesis that obstructions in CUAs increase uterine pressure and promote the development of adenomyosis remains to be further elucidated, and additional findings may also play a role. The patient's genetic, epigenetic, and hormonal patterns, as well as normal physiological processes, such as pregnancy, may influence the growth of adenomyosis.
子宫腺肌病和先天性子宫异常（CUA）会损害生殖潜能，且可能在同一患者中共存，尤其是在不孕症患者中。本综述（CRD42022382850）旨在评估已发表的子宫腺肌病与综合征性及非综合征性CUA并存的病例。使用以下数据库对从创建到2022年11月30日以英文发表的合适文章进行了文献检索：医学索引数据库（MEDLINE）、荷兰医学文摘数据库（EMBASE）、全球健康数据库、考克兰图书馆、卫生技术评估数据库和科学引文索引数据库（Web of Science）。纳入了包括CUA和子宫腺肌病且有关于它们潜在关系数据的文章。文献检索获得了14篇符合本综述目的的文章，并总结了关于子宫腺肌病和CUA同时诊断的最新发现。子宫腺肌病可在综合征性和非综合征性CUA中发现，且可能由多种病因引起。CUA中的梗阻会增加子宫压力并促进子宫腺肌病发展这一假说仍有待进一步阐明，其他发现也可能起作用。患者的遗传、表观遗传和激素模式，以及正常生理过程，如怀孕，可能会影响子宫腺肌病的生长。
