Hu Yu, Luo Shuying, Tang Xuewen, Lou Linqiao, Chen Yaping, Guo Jing, Zhang Bing
Zhejiang Center for Disease Control and Prevention, Institute of Immunization and Prevention, No. 3399 Binsheng Road, Binjiang District, Hangzhou, P. R. China.
Yiwu Center for Disease Control and Prevention, Institute of Immunization and Prevention, Yiwu, China.
BMC Public Health. 2015 Jul 15;15:664. doi: 10.1186/s12889-015-1998-5.
An EPI (Expanded Program on Immunization) intervention package was implemented from October 2011 to May 2014 among migrant children in Yiwu, east China. This study aimed to evaluate its impacts on vaccination coverage, maternal understanding of EPI and the local immunization service performance.
A pre- and post-test design was used. The EPI intervention package included: (1) extending the EPI service time and increasing the frequency of vaccination service; (2) training program for vaccinators; (3) developing a screening tool to identify vaccination demands among migrant clinic attendants; (4) Social mobilization for immunization. Data were obtained from random sampling investigations, vaccination service statistics and qualitative interviews with vaccinators and mothers of migrant children. The analysis of quantitative data was based on a "before and after" evaluation and qualitative data were analyzed using content analysis.
The immunization registration (records kept by immunization clinics) rate increased from 87.4 to 91.9% (P = 0.016) after implementation of the EPI intervention package and the EPI card holding (EPI card kept by caregivers) rate increased from 90.9 to 95.6% (P = 0.003). The coverage of fully immunized increased from 71.5 to 88.6% for migrant children aged 1-4 years (P < 0.001) and increased from 42.2 to 80.5% for migrant children aged 2-4 years (P < 0.001). The correct response rates on valid doses and management of adverse events among vaccinators were over 90% after training. The correct response rates on immunization among mothers of migrant children were 86.8-99.3% after interventions.
Our study showed a substantial improvement in vaccination coverage among migrant children in Yiwu after implementation of the EPI intervention package. Further studies are needed to evaluate the cost-effectiveness of the interventions, to identify individual interventions that make the biggest contribution to coverage, and to examine the sustainability of the interventions within the existing vaccination service delivery system in a larger scale settings or in a longer term.
2011年10月至2014年5月,在中国东部义乌的流动儿童中实施了一项扩大免疫规划(EPI)干预方案。本研究旨在评估其对疫苗接种率、母亲对扩大免疫规划的了解以及当地免疫服务绩效的影响。
采用前后测试设计。扩大免疫规划干预方案包括:(1)延长扩大免疫规划服务时间并增加疫苗接种服务频率;(2)为接种人员开展培训项目;(3)开发一种筛查工具,以识别流动诊所就诊者的疫苗接种需求;(4)开展免疫社会动员。数据来自随机抽样调查、疫苗接种服务统计以及对接种人员和流动儿童母亲的定性访谈。定量数据分析基于“前后”评估,定性数据分析采用内容分析法。
实施扩大免疫规划干预方案后,免疫登记(免疫诊所保存的记录)率从87.4%提高到91.9%(P = 0.016),EPI卡持有(照料者保存的EPI卡)率从90.9%提高到95.6%(P = 0.003)。1 - 4岁流动儿童的全程免疫覆盖率从71.5%提高到88.6%(P < 0.001),2 - 4岁流动儿童的全程免疫覆盖率从42.2%提高到80.5%(P < 0.001)。培训后,接种人员对有效剂量和不良事件管理的正确回答率超过90%。干预后,流动儿童母亲对免疫接种的正确回答率为86.8% - 99.3%。
我们的研究表明,实施扩大免疫规划干预方案后,义乌流动儿童的疫苗接种率有了显著提高。需要进一步研究来评估干预措施的成本效益,确定对覆盖率贡献最大的个体干预措施,并在更大规模环境或更长时期内检验现有疫苗接种服务体系中干预措施的可持续性。