一种用于胶原诱导血小板聚集的新指标。
A new index for collagen induced platelet aggregation.
作者信息
Kakishita E, Higuchi M, Suehiro A, Nagai K
机构信息
Second Department of Internal Medicine, Hyogo College of Medicine, Japan.
出版信息
Thromb Res. 1989 Nov 1;56(3):465-75. doi: 10.1016/0049-3848(89)90259-4.
In this paper, we propose a new index of platelet aggregation for optical aggregometry, the "R" value. This represents the rate of change in the half time for platelet aggregation (T1/2) induced by collagen with changes in the platelet concentration and expresses the degree of platelet sensitivity to collagen. The "R" value has been shown to reflect the aggregability of platelets due to activation of the contact factors. The "R" values were significantly different in the acute and chronic phases of occlusive arterial disease, while ordinary platelet aggregation parameters did not change. A decrease in the "R" value appears to indicate a platelet hyperfunction and hypercoagulable state, in other words a prethrombotic state.
在本文中，我们提出了一种用于光学凝集测定法的血小板聚集新指标，即“R”值。它代表了胶原诱导的血小板聚集半衰期（T1/2）随血小板浓度变化的变化率，并表达了血小板对胶原的敏感程度。“R”值已被证明可反映由于接触因子激活导致的血小板聚集能力。在闭塞性动脉疾病的急性期和慢性期，“R”值有显著差异，而普通血小板聚集参数没有变化。“R”值降低似乎表明血小板功能亢进和高凝状态，换句话说就是血栓前状态。
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