丁酰胆碱酯酶与肌肉质量和力量相关。一种用于识别有肌肉减少症风险的老年受试者的新型生物标志物。
Butyryl-cholinesterase is related to muscle mass and strength. A new biomarker to identify elderly subjects at risk of sarcopenia.
作者信息
Cacciatore Francesco, Della-Morte David, Basile Claudia, Curcio Francesco, Liguori Ilaria, Roselli Mario, Gargiulo Gaetano, Galizia Gianluigi, Bonaduce Domenico, Abete Pasquale
机构信息
Department of Translational Medical Sciences, University of Naples "Federico II," Naples, Italy.
IRCCS Salvatore Maugeri Foundation, Scientific Institute of Telese, Benevento, Italy.
出版信息
Biomark Med. 2015;9(7):669-78. doi: 10.2217/bmm.15.28.
AIMS
To determine the relationship between Butyryl-cholinesterase (α-glycoprotein synthesized in the liver, b-CHE) and muscle mass and strength.
METHODS
Muscle mass by bioimpedentiometer and muscle strength by grip strength were evaluated in 337 elderly subjects (mean age: 76.2 ± 6.7 years) admitted to comprehensive geriatric assessment.
RESULTS
b-CHE levels were lower in sarcopenic than in nonsarcopenic elderly subjects (p < 0.01). Linear regression analysis demonstrated that b-CHE is linearly related with grip strength and muscular mass both in men and women (r = 0.45 and r = 0.33, p < 0.01; r = 0.55 and r = 0.39, p < 0.01; respectively). Multivariate analysis confirms this analysis.
CONCLUSIONS
b-CHE is related to muscle mass and strength in elderly subjects. Thus, b-CHE may be considered to be a fair biomarker for identifying elderly subjects at risk of sarcopenia.
目的
确定丁酰胆碱酯酶（一种在肝脏中合成的α-糖蛋白，b-CHE）与肌肉质量和力量之间的关系。
方法
对337名接受综合老年评估的老年受试者（平均年龄：76.2±6.7岁）进行生物阻抗仪测量肌肉质量和握力评估肌肉力量。
结果
肌肉减少症患者的b-CHE水平低于非肌肉减少症老年受试者（p<0.01）。线性回归分析表明，b-CHE与男性和女性的握力和肌肉质量均呈线性相关（r分别为0.45和0.33，p<0.01；r分别为0.55和0.39，p<0.01）。多变量分析证实了这一分析结果。
结论
b-CHE与老年受试者的肌肉质量和力量相关。因此，b-CHE可被视为识别有肌肉减少症风险的老年受试者的一个合理生物标志物。
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