一种吲哚-三唑-罗丹明三元体系作为用于纳摩尔浓度水平汞（Ⅱ）高选择性传感的比率荧光探针。
A Indole-Trizole-Rhodamine Triad as Ratiometric Fluorescent Probe for Nanomolar-Concentration Level Hg(2+) Sensing with High Selectivity.
作者信息
Liu Heng, Ding Hui, Zhu Lili, Wang Yue, Chen Zili, Tian Zhiyuan
机构信息
School of Chemistry & Chemical Engineering, University of Chinese Academy of Sciences (UCAS), Beijing, 100049, China.
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules & College of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, People's Republic of China.
出版信息
J Fluoresc. 2015 Sep;25(5):1259-66. doi: 10.1007/s10895-015-1614-1. Epub 2015 Jul 17.
A new type of ratiometric fluorescent probe capable of detecting Hg(2+) ions at nanomolar-concentration level with high selectivity was developed based on an indole-trizole-rhodamine triad and its practicability for intracellular Hg(2+) sensing was verified. The as-prepared fluorescent probe is capable of detecting Hg(2+) over other competing metal ions including Ag(+) with high selectivity. The synergistic effect of Hg(2+)-assisted conversion of the nonfluorescent ring-closed rhodamine moiety to the highly fluorescent ring-open form as well as the fluorescence signal amplification originating from the Förster resonance energy transfer (FRET) from indole-trizole conjugate to rhodamine moiety contributed to a detection limit of 11 nM of the probe for Hg(2+) sensing.
基于吲哚 - 三唑 - 罗丹明三联体开发了一种新型比率荧光探针，该探针能够在纳摩尔浓度水平下高选择性地检测Hg(2+)离子，并验证了其在细胞内检测Hg(2+)的实用性。所制备的荧光探针能够高选择性地检测Hg(2+)，而不受包括Ag(+)在内的其他竞争性金属离子的干扰。Hg(2+)辅助将非荧光的闭环罗丹明部分转化为高荧光的开环形式的协同效应，以及源自吲哚 - 三唑共轭物到罗丹明部分的福斯特共振能量转移（FRET）的荧光信号放大，使得该探针对Hg(2+)传感的检测限达到11 nM。
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