Southeast Asia Disaster Prevention Research Initiative (SEADPRI-UKM), Institute for Environment and Development (LESTARI), Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia.
Department of Chemical Sciences, Faculty of Science & Technology, Universiti Kebangsaan Malaysia, Bangi 43600, Selangor, Malaysia.
Sensors (Basel). 2021 Jan 5;21(1):311. doi: 10.3390/s21010311.
Mass-spectrometry-based and X-ray fluorescence-based techniques have allowed the study of the distribution of Zn ions at extracellular and intracellular levels over the past few years. However, there are some issues during purification steps, sample preparation, suitability for quantification, and the instruments' availability. Therefore, work on fluorescent sensors based on 8-aminoquinoline as tools to detect Zn ions in environmental and biological applications has been popular. Introducing various carboxamide groups into an 8-aminoquinoline molecule to create 8-amidoquinoline derivatives to improve water solubility and cell membrane permeability is also a recent trend. This review aims to present a general overview of the fluorophore 8-aminoquinoline and its derivatives as Zn receptors for zinc sensor probes. Various fluorescent chemosensor designs based on 8-amidoquinoline and their effectiveness and potential as a recognition probe for zinc analysis were discussed. Based on this review, it can be concluded that derivatives of 8-amidoquinoline have vast potential as functional receptors for zinc ions primarily because of their fast reactivity, good selectivity, and bio-compatibility, especially for biological applications. To better understand the Zn ion fluorophores' function, diversity of the coordination complex and geometries need further studies. This review provides information in elucidating, designing, and exploring new 8-amidoquinoline derivatives for future studies for the improvement of chemosensors that are selective and sensitive to Zn.
基于质谱和 X 射线荧光的技术使得过去几年能够在细胞外和细胞内水平上研究锌离子的分布。然而，在纯化步骤、样品制备、定量适用性以及仪器的可用性方面存在一些问题。因此，基于 8-氨基喹啉的荧光传感器作为在环境和生物应用中检测锌离子的工具的研究受到了广泛关注。将各种酰胺基团引入 8-氨基喹啉分子中以创建 8-氨基喹啉衍生物，以提高水溶性和细胞膜通透性，也是最近的趋势。本综述旨在概述 8-氨基喹啉及其衍生物作为锌受体的荧光团，以及它们作为锌传感器探针的锌分析识别探针的有效性和潜力。讨论了基于 8-氨基喹啉的各种荧光化学传感器设计及其作为锌分析识别探针的有效性和潜力。基于本综述，可以得出结论，8-氨基喹啉的衍生物具有作为锌离子功能受体的巨大潜力，主要是因为它们具有快速的反应性、良好的选择性和生物相容性，特别是在生物应用中。为了更好地理解锌离子荧光团的功能，需要进一步研究配位络合物和几何形状的多样性。本综述提供了有关阐明、设计和探索新的 8-氨基喹啉衍生物的信息，以用于未来提高对锌具有选择性和敏感性的化学传感器的研究。
