Torre E, Pavesi M, Torre C
Boll Soc Ital Biol Sper. 1979 Aug 15;55(15):1515-9.
The indications for investigation on the LSD-25 "in vivo" activity on brain cholinesterases of the rat, have been considered. Indications of materials and method used have been supplied too. From the results obtained it emerged no clear evidence of a statistically significant inhibition of cholinesterases due to LSD-25. The results have been discussed and it has been evidenced that the lack of action of the psychotomimetic substance on cholinesterases could be only apparent or that the discrepancy between the LSD-25 anticholinesterase "in vivo" and "in vitro" action should be ascribed to the too scarce tissue levels which can be reached with the does utilized. Apart from the hypothesis, tending to explain the results obtained, it has been considered that the LSD-25 behavioural action, is not probably carried out thanks to a cholinesterase activity.
已对麦角酸二乙酰胺（LSD-25）对大鼠脑胆碱酯酶的“体内”活性进行研究的指征进行了考量。同时也提供了所使用材料和方法的说明。从获得的结果来看，没有明确证据表明LSD-25会对胆碱酯酶产生具有统计学意义的显著抑制作用。已对结果进行了讨论，并且已证明拟精神病物质对胆碱酯酶缺乏作用可能只是表面现象，或者LSD-25“体内”和“体外”抗胆碱酯酶作用之间的差异应归因于所使用剂量所能达到的组织水平过低。除了解释所获结果的假说外，人们还认为，LSD-25的行为作用可能并非通过胆碱酯酶活性来实现。
