Yang Wan-Qing, Song Yue-Lin, Zhu Zhi-Xiang, Su Cong, Zhang Xu, Wang Juan, Shi She-Po, Tu Peng-Fei
Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, People's Republic of China.
Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
Fitoterapia. 2015 Sep;105:187-93. doi: 10.1016/j.fitote.2015.07.006. Epub 2015 Jul 14.
Seven new dimeric furanocoumarins, dahuribiethrins A-G (1-7), were isolated from the roots of Angelica dahurica. Their structures were determined by chemical derivatization and extensive spectroscopic techniques, including (1)H NMR, (13)C NMR, HSQC, (1)H-(1)H COSY, HMBC, and NOESY experiments. Compounds 2, 3, 4, and 5 exhibited significant inhibition of nitric oxide production in the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells with IC50 values in the range of 8.8-9.8 μM.
从白芷根中分离出7种新的二聚体呋喃香豆素，即白芷双醚素A - G（1 - 7）。通过化学衍生化和广泛的光谱技术确定了它们的结构，包括（1）H NMR、（13）C NMR、HSQC、（1）H - （1）H COSY、HMBC和NOESY实验。化合物2、3、4和5在脂多糖（LPS）刺激的RAW264.7巨噬细胞中对一氧化氮的产生表现出显著抑制作用，IC50值在8.8 - 9.8 μM范围内。
