白芷根中的二聚体呋喃香豆素。
Dimeric furanocoumarins from the roots of Angelica dahurica.
作者信息
Yang Wan-Qing, Zhu Zhi-Xiang, Song Yue-Lin, Qi Bo-Wen, Wang Juan, Su Cong, Tu Peng-Fei, Shi She-Po
机构信息
a Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine , Beijing , China.
b School of Chinese Materia Medica , Beijing University of Chinese Medicine , Beijing , China.
出版信息
Nat Prod Res. 2017 Apr;31(8):870-877. doi: 10.1080/14786419.2016.1250090. Epub 2016 Oct 27.
Three new dimeric furanocoumarins, dahuribiethrins H-J (1-3), and a new ester coumarin, dahurinol A (4), were isolated from the roots of Angelica dahurica. Their structures were elucidated on the basis of extensive spectroscopic data including UV, IR, HRESIMS, 1D and 2D NMR. Compounds 2 and 3 exhibited inhibition of nitric oxide production in the lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells with IC values of 8.7 ± 0.6 and 27.3 ± 0.9 μM, respectively.
从白芷根中分离出三种新的二聚体呋喃香豆素，即白芷醚H-J（1-3），以及一种新的酯香豆素，即白当归脑A（4）。它们的结构是根据包括紫外光谱、红外光谱、高分辨电喷雾电离质谱、一维和二维核磁共振在内的大量光谱数据确定的。化合物2和3对脂多糖（LPS）刺激的RAW 264.7巨噬细胞中一氧化氮的产生具有抑制作用，其半数抑制浓度（IC）值分别为8.7±0.6和27.3±0.9μM。
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