Mirshafiey Abbas, Simhag Anita, El Rouby Nadia M M, Azizi Gholamreza
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Karolinska Institutet Science Park AB, Huddinge, Sweden.
Int J Dermatol. 2015 Aug;54(8):880-8. doi: 10.1111/ijd.12883.
T-helper 22 (Th22) cell is a new subset of CD4+ T cells that secrets interleukin (IL)-22 but not IL-17 or interferon-γ. Th22 is distinct from Th17 and other known CD4+ T-cell subsets with distinguished gene expression and function. Th22 subsets have chemokine receptors CCR6+ CCR4+ CCR10+ phenotype and aryl hydrocarbon receptor as the key transcription factor. This T-helper subset, by producing cytokines such as IL-22, IL-13, and tumor necrosis factor-α, is implicated in the pathogenesis of inflammatory skin disorder. This review discusses the role of Th22 and its cytokine IL-22 in the immunopathogenesis of inflammatory skin disorders such as psoriasis and atopic dermatitis.
辅助性T细胞22（Th22）是CD4 + T细胞的一个新亚群，它分泌白细胞介素（IL）-22，但不分泌IL-17或干扰素-γ。Th22与Th17及其他已知的CD4 + T细胞亚群不同，具有独特的基因表达和功能。Th22亚群具有趋化因子受体CCR6 + CCR4 + CCR10 +表型，并且芳烃受体是关键转录因子。这个辅助性T细胞亚群通过产生IL-22、IL-13和肿瘤坏死因子-α等细胞因子，参与炎症性皮肤病的发病机制。本文综述了Th22及其细胞因子IL-22在银屑病和特应性皮炎等炎症性皮肤病免疫发病机制中的作用。
