Durko Heather L, Furenlid Lars R
Center for Gamma-Ray Imaging, Department of Medical Imaging, University of Arizona, Tucson, Arizona ; College of Optical Sciences, University of Arizona, Tucson, Arizona.
Proc SPIE Int Soc Opt Eng. 2014 Aug 17;9214. doi: 10.1117/12.2066188.
Preclinical single-photon emission computed tomography (SPECT) is an essential tool for studying the progression, response to treatment, and physiological changes in small animal models of human disease. The wide range of imaging applications is often limited by the static design of many preclinical SPECT systems. We have developed a prototype imaging system that replaces the standard static pinhole aperture with two sets of movable, keel-edged copper-tungsten blades configured as crossed (skewed) slits. These apertures can be positioned independently between the object and detector, producing a continuum of imaging configurations in which the axial and transaxial magnifications are not constrained to be equal. We incorporated a megapixel silicon double-sided strip detector to permit ultrahigh-resolution imaging. We describe the configuration of the adjustable slit aperture imaging system and discuss its application toward adaptive imaging, and reconstruction techniques using an accurate imaging forward model, a novel geometric calibration technique, and a GPU-based ultra-high-resolution reconstruction code.
临床前单光子发射计算机断层扫描（SPECT）是研究人类疾病小动物模型的进展、治疗反应和生理变化的重要工具。许多临床前SPECT系统的静态设计常常限制了广泛的成像应用。我们开发了一种原型成像系统，该系统用两组配置成交叉（倾斜）狭缝的可移动、龙骨边缘的铜钨叶片取代了标准的静态针孔孔径。这些孔径可以独立地定位在物体和探测器之间，产生一系列成像配置，其中轴向和横向放大倍数不受限于相等。我们集成了一个百万像素硅双面条带探测器以实现超高分辨率成像。我们描述了可调狭缝孔径成像系统的配置，并讨论了其在自适应成像中的应用，以及使用精确成像前向模型、新颖的几何校准技术和基于GPU的超高分辨率重建代码的重建技术。
